Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity

被引:36
|
作者
Kissin, I
Bright, CA
Bradley, EL
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA
[2] Univ Alabama, Dept Biostat, Birmingham, AL 35294 USA
来源
ANESTHESIA AND ANALGESIA | 2002年 / 94卷 / 05期
关键词
D O I
10.1097/00000539-200205000-00038
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Capsaicin can produce a selective and long-lasting neural blockade. Resiniferatoxin (RTX) is an ultrapotent vanilloid agonist with a unique spectrum of activities different from that of capsaicin. We sought to determine whether a single application of RTX to a peripheral nerve could completely prevent the long-lasting mechanical hyperalgesia. caused by carrageenan injection. In rat experiments, RTX (0.001%) was administered percutaneously to the sciatic and saphenous nerves before the intraplantar injection of carrageenan. Responses to noxious mechanical (pressure on the paw) and thermal (hot plate) stimulations and changes in paw circumference were measured at various time intervals for 8 days after treatment. The administration of RTX resulted in mechanical and thermal hypoalgesia (for 2 and 8 days, respectively). Inflammatory hyperalgesia was completely prevented by the precarrageenan injection of RTX. Inflammatory enhancement of paw circumference was reduced by RTX (12.0 +/- 2.4 mm versus 6.9 +/- 3.4 mm, P < 0.005). We suggest that the selective nature of the effect of vanilloid agonists on nociception could provide an opportunity for prolonged neural blockade when early mobilization and/or preservation of protective sensation are required.
引用
收藏
页码:1253 / 1258
页数:6
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