Management and Successful Desensitization in Methotrexate-Induced Anaphylaxis

被引：11

作者：

Bouchireb, Karim ^{[1
]}

Dodille, Aurelie ^{[1
]}

Ponvert, Claude ^{[2
]}

Gouraud, Francois ^{[3
]}

Dubrel, Marie ^{[1
]}

Brugieres, Laurence ^{[1
]}

机构：

[1] Inst Gustave Roussy, Dept Pediat & Adolescent Oncol, F-94805 Villejuif, France

[2] Hosp Sick Children, Dept Pediat, Pulmonol & Allergy Unit, Paris, France

[3] Dept Pediat, Meaux, France

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 52卷 / 02期

关键词：

anaphylaxis; desensitization; methotrexate; HIGH-DOSE METHOTREXATE; LYMPHOMA; PATIENT;

D O I：

10.1002/pbc.21742

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anaphylactic/anaphylactoid reactions to methotrexate are rare. In patients with methotrexate-induced anaphylaxis, discontinuation of treatment may increase the risk of death due to cancer progression. In Such patients, desensitization may enable the patient to Continue treatment with methotrexate. We report the case of a child with metastatic osteosarcoma, who experienced in anaphylactic/anaphylactoid reaction to methotrexate. Skin tests with methotrexate were not performed because their diagnostic Value is controversial. Desensitization with methotrexate was Successful and allowed the patient to complete 12 additional Courses of chemotherapy. Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis. Pediatr Blood Cancer 2009;52:295-297. (C) 2008 Wiley-Liss, Inc.

引用

页码：295 / 297

页数：3

共 24 条

[1]

Alkins SA, 1996, CANCER, V77, P2123, DOI 10.1002/(SICI)1097-0142(19960515)77:10<2123::AID-CNCR24>3.0.CO

[2]

2-W

[3] ACUTE URTICARIA AND HEPATITIS COMPLICATING HIGH-DOSE METHOTREXATE THERAPY [J].

ALLAMKI, Z ;

THOMAS, E ;

ELBANNA, N ;

JAFFE, N .

MEDICAL AND PEDIATRIC ONCOLOGY, 1995, 24 (02) :137-140

[4] Anaphylactoid reaction to high-dose methotrexate and re-administration after a successful desensitization [J].

Caldeira, Teresa ;

Costa, Vitor ;

Silva, Isabel ;

Oliva, Tereza ;

Norton, Lucilia .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2008, 25 (02) :131-134

[5] Successful desensitization to high-dose methotrexate after systemic anaphylaxis [J].

Davis, KA ;

Williams, P ;

Walker, JC .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2003, 90 (01) :87-89

[6]

Devecioglu Ö, 2000, MED PEDIATR ONCOL, V34, P151, DOI 10.1002/(SICI)1096-911X(200002)34:2<151::AID-MPO17>3.0.CO

[7]

2-V

[8] Systemic anaphylactic reaction following intrathecal administration of methotrexate in adult patient with primary central nervous system lymphoma [J].

Elkiran, ET ;

Altundag, K ;

Aksoy, S ;

Onal, IK ;

Tekuzman, G .

AMERICAN JOURNAL OF HEMATOLOGY, 2004, 75 (04) :265-265

[9]

GLUCKKUYT I, 1979, CANCER TREAT REP, V63, P797

[10]

GOLDBERG NH, 1978, CANCER-AM CANCER SOC, V41, P52, DOI 10.1002/1097-0142(197801)41:1<52::AID-CNCR2820410109>3.0.CO

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