Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells

被引:169
作者
Guo, Ruihua [1 ]
Zhou, Shixin [2 ]
Li, Yunchao [1 ]
Li, Xiaohong [1 ]
Fan, Louzhen [1 ]
Voelcker, Nicolas H. [3 ]
机构
[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Sch Basic Med, Dept Cell Biol, Beijing 100191, Peoples R China
[3] Univ S Australia, ARC Ctr Excellence Convergent Bionano Sci & Tech, Mawson Lakes, SA 5095, Australia
基金
澳大利亚研究理事会;
关键词
graphene quantum dots; rhodamine B derivative; detection; Fe3+; cancer stem cells; FLUORESCENT SENSING PLATFORM; IRON REGULATORY PROTEINS; LABEL-FREE DETECTION; FACILE SYNTHESIS; SELECTIVE DETECTION; CARBON NANODOTS; UP-CONVERSION; PROBE; NANOPARTICLES; CHEMOSENSORS;
D O I
10.1021/acsami.5b06523
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe3+ detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 mu M are demonstrated as a Fe3+ turn-on fluorescent nanosensor in cancer stem cells. Fe3+ binding to such GQDs (RBD-GQDs-Fe3+) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
引用
收藏
页码:23958 / 23966
页数:9
相关论文
共 59 条
[41]   Recent progress in the development of fluorometric and colorimetric chemosensors for detection of cyanide ions [J].
Wang, Fang ;
Wang, Li ;
Chen, Xiaoqiang ;
Yoon, Juyoung .
CHEMICAL SOCIETY REVIEWS, 2014, 43 (13) :4312-4324
[42]   A naked-eye rhodamine-based fluorescent probe for Fe(III) and its application in living cells [J].
Wang, Shuxin ;
Meng, Xiangming ;
Zhu, Manzhou .
TETRAHEDRON LETTERS, 2011, 52 (22) :2840-2843
[43]   New sensing mechanisms for design of fluorescent chemosensors emerging in recent years [J].
Wu, Jiasheng ;
Liu, Weimin ;
Ge, Jiechao ;
Zhang, Hongyan ;
Wang, Pengfei .
CHEMICAL SOCIETY REVIEWS, 2011, 40 (07) :3483-3495
[44]   Colorimetric detection of Fe3+ ions using pyrophosphate functionalized gold nanoparticles [J].
Wu, Shu-Pao ;
Chen, Yi-Pu ;
Sung, Yi-Ming .
ANALYST, 2011, 136 (09) :1887-1891
[45]   Quantum dot based turn-on fluorescent probes for anion sensing [J].
Xia, Yunsheng ;
Wang, Jiajing ;
Zhang, Yuzhong ;
Song, Lei ;
Ye, Jingjing ;
Yang, Guang ;
Tan, Kanghui .
NANOSCALE, 2012, 4 (19) :5954-5959
[46]   A new rhodamine-based chemosensor exhibiting selective FeIII-amplified fluorescence [J].
Xiang, Y ;
Tong, AJ .
ORGANIC LETTERS, 2006, 8 (08) :1549-1552
[47]   Nanoreactor-confined synthesis and separation of yellow-luminescent graphene quantum dots with a recyclable SBA-15 template and their application for Fe(III) sensing [J].
Xu, Hongbo ;
Zhou, Shenghai ;
Xiao, Lili ;
Li, Shouzhu ;
Song, Ting ;
Wang, Yi ;
Yuan, Qunhui .
CARBON, 2015, 87 :215-225
[48]   Cyclodextrin Supramolecular Complex as a Water-Soluble Ratiometric Sensor for Ferric Ion Sensing [J].
Xu, Meiyun ;
Wu, Shuizhu ;
Zeng, Fang ;
Yu, Changmin .
LANGMUIR, 2010, 26 (06) :4529-4534
[49]   Preparation of highly photoluminescent sulfur-doped carbon dots for Fe(III) detection [J].
Xu, Quan ;
Pu, Peng ;
Zhao, Jungang ;
Dong, Chenbo ;
Gao, Chun ;
Chen, Yusheng ;
Chen, Jiarui ;
Liu, Yao ;
Zhou, Hongjun .
JOURNAL OF MATERIALS CHEMISTRY A, 2015, 3 (02) :542-546
[50]   Cancer stem cells [J].
Yu, Zuoren ;
Pestell, Timothy G. ;
Lisanti, Michael P. ;
Pestell, Richard G. .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (12) :2144-2151