Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells

被引：169

作者：

Guo, Ruihua ^{[1
]}

Zhou, Shixin ^{[2
]}

Li, Yunchao ^{[1
]}

Li, Xiaohong ^{[1
]}

Fan, Louzhen ^{[1
]}

Voelcker, Nicolas H. ^{[3
]}

机构：

[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China

[2] Peking Univ, Hlth Sci Ctr, Sch Basic Med, Dept Cell Biol, Beijing 100191, Peoples R China

[3] Univ S Australia, ARC Ctr Excellence Convergent Bionano Sci & Tech, Mawson Lakes, SA 5095, Australia

来源：

ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 43期

基金：

澳大利亚研究理事会;

关键词：

graphene quantum dots; rhodamine B derivative; detection; Fe3+; cancer stem cells; FLUORESCENT SENSING PLATFORM; IRON REGULATORY PROTEINS; LABEL-FREE DETECTION; FACILE SYNTHESIS; SELECTIVE DETECTION; CARBON NANODOTS; UP-CONVERSION; PROBE; NANOPARTICLES; CHEMOSENSORS;

D O I：

10.1021/acsami.5b06523

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe3+ detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 mu M are demonstrated as a Fe3+ turn-on fluorescent nanosensor in cancer stem cells. Fe3+ binding to such GQDs (RBD-GQDs-Fe3+) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.

引用

页码：23958 / 23966

页数：9

共 59 条

[41] Recent progress in the development of fluorometric and colorimetric chemosensors for detection of cyanide ions [J].

Wang, Fang ;

Wang, Li ;

Chen, Xiaoqiang ;

Yoon, Juyoung .

CHEMICAL SOCIETY REVIEWS, 2014, 43 (13) :4312-4324

[42] A naked-eye rhodamine-based fluorescent probe for Fe(III) and its application in living cells [J].

Wang, Shuxin ;

Meng, Xiangming ;

Zhu, Manzhou .

TETRAHEDRON LETTERS, 2011, 52 (22) :2840-2843

[43] New sensing mechanisms for design of fluorescent chemosensors emerging in recent years [J].

Wu, Jiasheng ;

Liu, Weimin ;

Ge, Jiechao ;

Zhang, Hongyan ;

Wang, Pengfei .

CHEMICAL SOCIETY REVIEWS, 2011, 40 (07) :3483-3495

[44] Colorimetric detection of Fe3+ ions using pyrophosphate functionalized gold nanoparticles [J].

Wu, Shu-Pao ;

Chen, Yi-Pu ;

Sung, Yi-Ming .

ANALYST, 2011, 136 (09) :1887-1891

[45] Quantum dot based turn-on fluorescent probes for anion sensing [J].

Xia, Yunsheng ;

Wang, Jiajing ;

Zhang, Yuzhong ;

Song, Lei ;

Ye, Jingjing ;

Yang, Guang ;

Tan, Kanghui .

NANOSCALE, 2012, 4 (19) :5954-5959

[46] A new rhodamine-based chemosensor exhibiting selective FeIII-amplified fluorescence [J].

Xiang, Y ;

Tong, AJ .

ORGANIC LETTERS, 2006, 8 (08) :1549-1552

[47] Nanoreactor-confined synthesis and separation of yellow-luminescent graphene quantum dots with a recyclable SBA-15 template and their application for Fe(III) sensing [J].

Xu, Hongbo ;

Zhou, Shenghai ;

Xiao, Lili ;

Li, Shouzhu ;

Song, Ting ;

Wang, Yi ;

Yuan, Qunhui .

CARBON, 2015, 87 :215-225

[48] Cyclodextrin Supramolecular Complex as a Water-Soluble Ratiometric Sensor for Ferric Ion Sensing [J].

Xu, Meiyun ;

Wu, Shuizhu ;

Zeng, Fang ;

Yu, Changmin .

LANGMUIR, 2010, 26 (06) :4529-4534

[49] Preparation of highly photoluminescent sulfur-doped carbon dots for Fe(III) detection [J].

Xu, Quan ;

Pu, Peng ;

Zhao, Jungang ;

Dong, Chenbo ;

Gao, Chun ;

Chen, Yusheng ;

Chen, Jiarui ;

Liu, Yao ;

Zhou, Hongjun .

JOURNAL OF MATERIALS CHEMISTRY A, 2015, 3 (02) :542-546

[50] Cancer stem cells [J].

Yu, Zuoren ;

Pestell, Timothy G. ;

Lisanti, Michael P. ;

Pestell, Richard G. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (12) :2144-2151

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