Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells

被引：169
作者：
Guo, Ruihua [1 ]
Zhou, Shixin [2 ]
Li, Yunchao [1 ]
Li, Xiaohong [1 ]
Fan, Louzhen [1 ]
Voelcker, Nicolas H. [3 ]
机构：
[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Sch Basic Med, Dept Cell Biol, Beijing 100191, Peoples R China
[3] Univ S Australia, ARC Ctr Excellence Convergent Bionano Sci & Tech, Mawson Lakes, SA 5095, Australia
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 43期
基金：
澳大利亚研究理事会;
关键词：
graphene quantum dots; rhodamine B derivative; detection; Fe3+; cancer stem cells; FLUORESCENT SENSING PLATFORM; IRON REGULATORY PROTEINS; LABEL-FREE DETECTION; FACILE SYNTHESIS; SELECTIVE DETECTION; CARBON NANODOTS; UP-CONVERSION; PROBE; NANOPARTICLES; CHEMOSENSORS;
D O I：
10.1021/acsami.5b06523
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe3+ detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 mu M are demonstrated as a Fe3+ turn-on fluorescent nanosensor in cancer stem cells. Fe3+ binding to such GQDs (RBD-GQDs-Fe3+) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
引用
收藏
页码：23958 / 23966
页数：9
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