Cytocompatibility and antibacterial properties of zirconia coatings with different silver contents on titanium

被引：33

作者：

Huang, Heng-Li ^{[1
]}

Chang, Yin-Yu ^{[2
]}

Chen, Ya-Chi ^{[3
]}

Lai, Chih-Ho ^{[4
]}

Chen, Michael Y. C. ^{[1
,5
]}

机构：

[1] China Med Univ, Sch Dent, Taichung 404, Taiwan

[2] Natl Formosa Univ, Dept Mech & Comp Aided Engn, Yunlin 632, Taiwan

[3] Mingdao Univ, Dept Mat Sci & Engn, Changhua 52345, Taiwan

[4] China Med Univ, Sch Med, Taichung 404, Taiwan

[5] China Med Univ Hosp, Div Oral & Maxillofacial Surg, Taichung 404, Taiwan

来源：

THIN SOLID FILMS | 2013年 / 549卷

关键词：

Zirconia; Silver; Coating; Human gingival fibroblast cells; S; aureus; A; actinomycetemcomitans; Antibacterial; HUMAN GINGIVAL FIBROBLASTS; STAPHYLOCOCCUS-AUREUS; THIN-FILMS; IN-VITRO; ADHESION; OXIDE; BIOCOMPATIBILITY; NANOPARTICLES; DEPOSITION; MORPHOLOGY;

D O I：

10.1016/j.tsf.2013.07.075

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This study used a twin-gun magnetron sputtering system to deposit ZrO2-silver (Ag) coatings on biograde pure-titanium implant materials, and the Ag content in the deposited coatings was controlled by the magnetron power. The films were then annealed using rapid thermal annealing at 350 degrees C for 2 min to induce the nucleation and growth of nanoparticles on the film surface. Staphylococcus aureus (S. aureus) and Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) were used for in vitro antibacterial analyses. The cytocompatibility, mRNA expression, and adhesive morphology of human gingival fibroblast (HGF) cells on the coatings were also determined. The obtained results suggest that ZrO2-Ag composite coatings containing less than 10.6 at.% Ag show hydrophobicity, good viability and proliferation of HGF cells, and antibacterial effects on S. aureus and A. actinomycetemcomitans. Moreover, the antibacterial performance of ZrO2-Ag coatings is superior to that pure-titanium whilst maintaining biological compatibility. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：108 / 116

页数：9

共 49 条

[1] INVITRO AND INVIVO COMPARATIVE COLONIZATION OF STAPHYLOCOCCUS-AUREUS AND STAPHYLOCOCCUS-EPIDERMIDIS ON ORTHOPEDIC IMPLANT MATERIALS [J].