Puberty as an accelerator for diabetes complications

被引：107

作者：

Cho, Yoon Hi ^{[1
,2
]}

Craig, Maria E. ^{[1
,2
,3
]}

Donaghue, Kim C. ^{[1
,2
]}

机构：

[1] Childrens Hosp Westmead, Inst Endocrinol & Diabet, Sydney, NSW, Australia

[2] Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia

[3] Univ New S Wales, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

来源：

PEDIATRIC DIABETES | 2014年 / 15卷 / 01期

关键词：

adolescent diabetes; androgens; insulin resistance; puberty; vascular complications; HORMONE-BINDING GLOBULIN; STAGE RENAL-DISEASE; POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; MICROVASCULAR COMPLICATIONS; GROWTH-HORMONE; METABOLIC-CONTROL; GLYCEMIC CONTROL; RISK-FACTORS; ENDOTHELIAL FUNCTION;

D O I：

10.1111/pedi.12112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Much is written about how difficult it is to deal with diabetes during adolescence, and rightly so. Less is understood as to how puberty may be an accelerator of vascular complications. With the increase in childhood diabetes, complication risks need to be revisited in relation to puberty and the secular increase in adiposity. Recent data suggest greater risk for severe vascular complications in those with diabetes during puberty, compared with young people who develop diabetes after puberty. It is also widely recognized that higher hemoglobin A1c (HbA1c) results are often seen during the pubertal period. This article will review complication outcomes in relation to puberty and examine mechanisms by which puberty may modify risk above glycemic exposure, and possible gender disparities in the risk of complications in the adolescent period.

引用

页码：18 / 26

页数：9

共 66 条

[61] Sex hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the study of women across the nation (SWAN) [J].