Sex-biased cellular signaling: molecular basis for sex differences in neuropsychiatric diseases

被引:1
|
作者
Valentino, Rita J. [1 ,2 ]
Bangasser, Debra A. [3 ,4 ]
机构
[1] Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care Med, Philadelphia, PA USA
[2] Univ Penn, Philadelphia, PA 19104 USA
[3] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA
[4] Temple Univ, Neurosci Program, Philadelphia, PA 19122 USA
关键词
amygdala; arousal; beta-arrestin; corticotropin-releasing factor; G-GTP; binding protein; locus coeruleus; norepinephrine; stress; CORTICOTROPIN-RELEASING-FACTOR; LOCUS-COERULEUS NEURONS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; POSTTRAUMATIC-STRESS-DISORDER; FACTOR-LIKE IMMUNOREACTIVITY; NATIONAL-COMORBIDITY-SURVEY; HORMONE-EXPRESSING NEURONS; ALZHEIMERS-DISEASE; DEPRESSED-PATIENTS; FACTOR RECEPTORS;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The recognition that there are fundamental biological sex differences that extend beyond those that define sexual behavior and reproductive function has inspired the drive toward inclusion of both sexes in research design. This is supported by an underlying clinical rationale that studying both sexes is necessary to elucidate pathophysiology and develop treatments for the entire population. However, at a more basic level, sex differences, like genetic differences, can be exploited to better understand biology. Here, we discuss how sex differences at the molecular level of cell signaling and protein trafficking are amplified to create a state of vulnerability that under the right conditions can result in symptoms of neuropsychiatric disease. Although this dialogue focuses on the specific example of corticotro-pin-releasing factor, the potential for analogous sex differences in signaling and/or trafficking of receptors for other neuromodulators has broad biological and therapeutic implications. (C) 2016, AICH - Servier Research Group
引用
收藏
页码:385 / 393
页数:9
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