Histone Deacetylases Enzyme, Copper, and IL-8 Levels in Patients With Alzheimer's Disease

被引：67
作者：
Alsadany, Mohamad A. [1 ]
Shehata, Hanan H. [2 ]
Mohamad, Magda I. [2 ]
Mahfouz, Riham G. [3 ]
机构：
[1] Ain Shams Univ, Fac Med, Dept Geriatr, Cairo 002, Egypt
[2] Ain Shams Univ, Fac Med, Dept Med Biochem, Cairo 002, Egypt
[3] Al Menoufiya Univ, Fac Med, Dept Med Biochem, Al Menoufiya, Egypt
来源：
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2013年 / 28卷 / 01期
关键词：
AD; cognitive function; epigenetics; inflammation; HDACs; copper; IL-8; SERUM COPPER; CYTOKINES; IRON; INTERLEUKIN-8; INFLAMMATION; IMPAIRMENT; DEMENTIA; ZINC;
D O I：
10.1177/1533317512467680
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities. Epigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease. We aimed to detect noninvasive peripheral biomarkers with a high degree of sensitivity and specificity in diagnosis and progression of AD. Methods: A total of 25 elderly patients with AD and 25 healthy control participants were selected and subjected to cognitive assessment and laboratory measures including histone deacetylases (HDACs), copper, and interleukin 8 (IL-8) levels. Results: The levels of HDACs, copper, and IL-8 were significantly higher in patients with AD (P < .001) and had a significant negative effect on all cognitive assessment tests. Receiver-operating curve (ROC) analysis revealed that HDACs and copper levels had higher sensitivity and specificity. Conclusions: Plasma levels of HDACs and copper may be used as peripheral biomarkers in diagnosis of AD, while IL-8 level could be a useful biomarker in following AD progression.
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页码：54 / 61
页数：8
相关论文
共 49 条
  • [1] Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
    Abe, Ted
    Zukin, R. Suzanne
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2008, 8 (01) : 57 - 64
  • [2] CYTOKINES IN ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA
    Angelopoulos, P.
    Agouridaki, H.
    Vaiopoulos, H.
    Siskou, E.
    Doutsou, K.
    Costa, V.
    Baloyiannis, S. I.
    [J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2008, 118 (12) : 1659 - 1672
  • [3] [Anonymous], 2000, DSM 4 TR DIAGN STAT
  • [4] [Anonymous], 2001, INT PSYCHOGERIATR
  • [5] CONTROL OF SHORT-TERM MEMORY
    ATKINSON, RC
    SHIFFRIN, RM
    [J]. SCIENTIFIC AMERICAN, 1971, 225 (02) : 82 - &
  • [6] BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
  • [7] Histone deacetylase inhibitors: gathering pace
    Carey, Nessa
    La Thangue, Nicholas B.
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2006, 6 (04) : 369 - 375
  • [8] Peripheral inflammatory response in Alzheimer's disease and multiinfarct dementia
    De Luigi, A
    Pizzimenti, S
    Quadri, P
    Lucca, U
    Tettamanti, M
    Fragiacomo, C
    De Simoni, MG
    [J]. NEUROBIOLOGY OF DISEASE, 2002, 11 (02) : 308 - 314
  • [9] Ferrante RJ, 2003, J NEUROSCI, V23, P9418
  • [10] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN
    FOLSTEIN, MF
    FOLSTEIN, SE
    MCHUGH, PR
    [J]. JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) : 189 - 198
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