Characterization of xanthatin: Anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo

被引：34
作者：
Li, Wei D. [1 ,2 ]
Wu, Yu [1 ,2 ]
Zhang, Lei [3 ]
Yan, Ling G. [1 ,5 ]
Yin, Fang Z. [1 ,2 ]
Ruan, Jun S. [4 ]
Chen, Zhi P. [1 ,2 ]
Yang, Guang M. [1 ,2 ]
Yan, Cui P. [1 ,2 ]
Zhao, Ding [1 ]
Lu, Yin [1 ,5 ]
Cai, Bao C. [1 ,2 ,6 ]
机构：
[1] Nanjing Univ Chinese Med, Nanjing 210046, Jiangsu, Peoples R China
[2] State Minist Educ Standardizat Chinese Med Proc, Ctr Engn, Nanjing 210046, Jiangsu, Peoples R China
[3] Anhui Prov Hosp, Dept Pharm, Hefei 230001, Peoples R China
[4] Fujian Med Univ, Clin Coll, Fujian Prov Hosp, Fujian 350001, Peoples R China
[5] Chinese Mat Med, Jiangsu Key Lab Pharmacol & Safety Evaluat, Nanjing 210029, Jiangsu, Peoples R China
[6] Nanjing Haichang Chinese Med Grp Corp, Nanjing 210061, Jiangsu, Peoples R China
来源：
PHYTOMEDICINE | 2013年 / 20卷 / 10期
关键词：
Xanthatin; Apoptosis; Wnt/beta-catenin signaling; Melanoma; XANTHIUM-STRUMARIUM L; CELL-CYCLE ARREST; BETA-CATENIN; SESQUITERPENE LACTONES; PATHWAY; APOPTOSIS; XANTHANOLIDES; CARCINOMA; TARGET;
D O I：
10.1016/j.phymed.2013.03.006
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo. MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of beta-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely. All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/beta-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis. (C) 2013 Elsevier GmbH. All rights reserved.
引用
收藏
页码：865 / 873
页数：9
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