The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis

被引：43
|
作者：
Prieto-Perez, Rocio [1 ]
Solano-Lopez, Guillermo [2 ]
Cabaleiro, Teresa [1 ,3 ]
Roman, Manuel [1 ]
Ochoa, Dolores [1 ]
Talegon, Maria [1 ]
Baniandres, Ofelia [4 ]
Lopez Estebaranz, Jose Luis [5 ]
de la Cueva, Pablo [6 ]
Dauden, Esteban [2 ]
Abad-Santos, Francisco [1 ,3 ]
机构：
[1] Univ Autonoma Madrid, Inst Invest Sanitaria Princesa IP, Hosp Univ Princesa, Clin Pharmacol Serv,Inst Teofilo Hernando, Madrid, Spain
[2] Hosp Univ Princesa, Inst Invest Sanitaria Princesa IP, Dermatol Serv, Madrid, Spain
[3] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepaticas & Di, Madrid 28029, Spain
[4] Hosp Univ Gregorio Maranon, Dermatol Serv, Madrid 28007, Spain
[5] Hosp Univ Fdn Alcorcon, Dermatol Serv, Madrid 28922, Spain
[6] Hosp Univ Infanta Leonor, Dermatol Serv, Madrid 28031, Spain
来源：
PHARMACOGENOMICS | 2015年 / 16卷 / 15期
关键词：
adalimumab; etanercept; IL-17; infliximab; pharmacogenetics; psoriasis; rs763780; rs10484879; rs2275913; ustekinumab; ANTI-TNF THERAPY; INTERLEUKIN; 17A; SUSCEPTIBILITY; ARTHRITIS; IL17A; ASTHMA;
D O I：
10.2217/pgs.15.107
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Psoriasis improves when IL-17 is blocked. Anti-TNF drugs reduce the IL-17 signaling pathway, and anti-IL-17 drugs are being developed to treat moderate-to-severe psoriasis. We analyzed three SNPs in IL-17A (rs2275913 and rs10484879) and IL-17F (rs763780) to look for an association with psoriasis and/or with response to anti-TNF drugs or ustekinumab. We included 197 healthy controls and 194 patients with moderate-to-severe psoriasis. The results of the univariate analysis showed an association between rs10484879 and psoriasis, although this relationship disappeared after adjustment for HLA-C (rs12191877). We also found an association between rs763780 (IL-17F) and response to ustekinumab (n = 70) and infliximab (n = 37) at 3 and 6 months and an association between rs763780 and the response to adalimumab at 6 months (n = 67).
引用
收藏
页码：1723 / 1731
页数：9
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