Love and death: microglia, NLRP3 and the Alzheimer's brain

被引：44
|
作者：
Goldmann, Tobias [1 ]
Tuan Leng Tay [1 ]
Prinz, Marco [1 ,2 ]
机构：
[1] Univ Freiburg, Inst Neuropathol, Freiburg, Germany
[2] Univ Freiburg, BIOSS Ctr Biol Signalling, Freiburg, Germany
来源：
CELL RESEARCH | 2013年 / 23卷 / 05期
关键词：
MYELOID CELLS; INFLAMMASOME; DISEASE; DERIVE;
D O I：
10.1038/cr.2013.24
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Microglia were previously attributed to be vital brain guardians for neuronal survival and synaptic pruning during development as well as for the brain's fight against environmental pathogens. A new report in Nature by the Heneka, Latz and Golenbock groups, however, sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration.
引用
收藏
页码：595 / 596
页数：2
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