Unprecedented Hemiketal Cembranolides with Anti-inflammatory Activity from the Soft Coral Lobophytum durum

被引：42

作者：

Cheng, Shi-Yie ^{[1
]}

Wen, Zhi-Hong ^{[1
,5
]}

Wang, Shang-Kwei ^{[2
]}

Chiou, Shu-Fen ^{[1
]}

Hsu, Chi-Hsin ^{[1
,5
]}

Dai, Chang-Feng ^{[3
]}

Chiang, Michael Y. ^{[4
]}

Duh, Chang-Yih ^{[1
,5
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung, Taiwan

[3] Natl Taiwan Univ, Inst Oceanog, Taipei 10764, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Ctr Asia Pacific Marine Res, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 01期

关键词：

SINULARIA-FLEXIBILIS; DITERPENES; CRASSUM;

D O I：

10.1021/np800686k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigations of the soft coral Lobophytum durum have led to the isolation of three unprecedented hemiketal cembranolides, durumhemiketalolides A-C (1-3). Full NMR spectroscopic assignments are provided for all isolated metabolites. The anti-inflammatory activities of 1-3 were evaluated in vitro.

引用

页码：152 / 155

页数：4

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