Unprecedented Hemiketal Cembranolides with Anti-inflammatory Activity from the Soft Coral Lobophytum durum

被引：41

作者：

Cheng, Shi-Yie ^{[1
]}

Wen, Zhi-Hong ^{[1
,5
]}

Wang, Shang-Kwei ^{[2
]}

Chiou, Shu-Fen ^{[1
]}

Hsu, Chi-Hsin ^{[1
,5
]}

Dai, Chang-Feng ^{[3
]}

Chiang, Michael Y. ^{[4
]}

Duh, Chang-Yih ^{[1
,5
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung, Taiwan

[3] Natl Taiwan Univ, Inst Oceanog, Taipei 10764, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Ctr Asia Pacific Marine Res, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 01期

关键词：

SINULARIA-FLEXIBILIS; DITERPENES; CRASSUM;

D O I：

10.1021/np800686k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigations of the soft coral Lobophytum durum have led to the isolation of three unprecedented hemiketal cembranolides, durumhemiketalolides A-C (1-3). Full NMR spectroscopic assignments are provided for all isolated metabolites. The anti-inflammatory activities of 1-3 were evaluated in vitro.

引用

页码：152 / 155

页数：4

共 14 条

[1] Marine natural products
Blunt, John W.
Copp, Brent R.
Hu, Wan-Ping
Munro, Murray H. G.
Northcote, Peter T.
Prinsep, Michele R.
[J]. NATURAL PRODUCT REPORTS, 2008, 25 (01) : 35 - 94
[2] THE STRUCTURES OF 4 ISOMERIC DIHYDROFURAN-CONTAINING CEMBRANOID DITERPENES FROM SEVERAL SPECIES OF SOFT CORAL
BOWDEN, BF
COLL, JC
HEATON, A
KONIG, G
BRUCK, MA
CRAMER, RE
KLEIN, DM
SCHEUER, PJ
[J]. JOURNAL OF NATURAL PRODUCTS, 1987, 50 (04): : 650 - 659
[3] Durumolides A-E, anti-inflammatory and antibacterial cembranolides from the soft coral Lobophytum durum
Cheng, Shi-Yie
Wen, Zhi-Hong
Chiou, Shu-Fen
Hsu, Chi-Hsin
Wang, Shang-Kewi
Dai, Chang-Feng
Chiang, Michael Y.
Duh, Chang-Yih
[J]. TETRAHEDRON, 2008, 64 (41) : 9698 - 9704
[4] A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli
Coval, SJ
Patton, RW
Petrin, JM
James, L
Rothofsky, ML
Lin, SL
Patel, M
Reed, JK
McPhail, AT
Bishop, WR
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) : 909 - 912
[5] Cytotoxic cembrenolide diterpenes from the formosan soft coral Lobophytum crassum
Duh, CY
Wang, SK
Huang, BT
Dai, CF
[J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (06): : 884 - 885
[6] A novel cytotoxic biscembranoid from the formosan soft coral Sinularia flexibilis
Duh, CY
Wang, SK
Tseng, HK
Sheu, JH
[J]. TETRAHEDRON LETTERS, 1998, 39 (39) : 7121 - 7122
[7] Novel cytotoxic cembranoids from the soft coral Sinularia flexibilis
Duh, CY
Wang, SK
Tseng, HK
Sheu, JH
Chiang, MY
[J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (06): : 844 - 847
[8] Cytotoxic and ichthyotoxic compounds from marine opisthobranchia and soft coral
Higuchi, R
Miyamoto, T
Yamada, K
Komori, T
[J]. TOXICON, 1998, 36 (11) : 1703 - 1705
[9] New marine diterpenoids from the Okinawan soft coral Clavularia koellikeri
Iwashima, M
Matsumoto, Y
Takenaka, Y
Iguchi, K
Yamori, T
[J]. JOURNAL OF NATURAL PRODUCTS, 2002, 65 (10): : 1441 - 1446
[10] Three new diterpenes from the marine soft coral Lobophytum crassum
Matthée, GF
König, GM
Wright, AD
[J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (02): : 237 - 240

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