N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists

被引：52

作者：

Doherty, GA ^{[1
]}

Kamenecka, T

McCauley, E

Van Riper, G

Mumford, RA

Tong, S

Hagmann, WK

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Immunol & Rheumatol, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(02)00009-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar activity against VLA-4. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：729 / 731

页数：3

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