An unusual synthesis of 2-pyridone and 3,5-dihydroxypyridine from a carbohydrate

被引：6
|
作者：
Gorantla, Jaggaiah N. [1 ]
Kovval, Divya [1 ]
Lankalapalli, Ravi S. [1 ]
机构：
[1] CSIR, NIIST, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 25期
关键词：
2-Pyridone; 3,5-Dihydroxypyridine; INHIBITORS; CYCLOADDITION; CAMPTOTHECIN; DESIGN; SERIES;
D O I：
10.1016/j.tetlet.2013.03.083
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unusual aromatization to perbenzylated 3,5-dihydroxy-6-(hydroxymethyl)-2-pyridone was demonstrated utilizing sugar lactam, under strong basic conditions, derived from D-Galactose. 2-Pyridone was efficiently converted into a pharmaceutically relevant structure 3,5-dihydroxy pyridine salt to demonstrate its synthetic utility. This result is the first report for 2-pyridone synthesis from a carbohydrate, and also first of its kind for a novel 3,5-dihydroxypyridine. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3230 / 3232
页数：3
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