An unusual synthesis of 2-pyridone and 3,5-dihydroxypyridine from a carbohydrate

被引：6

作者：

Gorantla, Jaggaiah N. ^{[1
]}

Kovval, Divya ^{[1
]}

Lankalapalli, Ravi S. ^{[1
]}

机构：

[1] CSIR, NIIST, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 25期

关键词：

2-Pyridone; 3,5-Dihydroxypyridine; INHIBITORS; CYCLOADDITION; CAMPTOTHECIN; DESIGN; SERIES;

D O I：

10.1016/j.tetlet.2013.03.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unusual aromatization to perbenzylated 3,5-dihydroxy-6-(hydroxymethyl)-2-pyridone was demonstrated utilizing sugar lactam, under strong basic conditions, derived from D-Galactose. 2-Pyridone was efficiently converted into a pharmaceutically relevant structure 3,5-dihydroxy pyridine salt to demonstrate its synthetic utility. This result is the first report for 2-pyridone synthesis from a carbohydrate, and also first of its kind for a novel 3,5-dihydroxypyridine. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3230 / 3232

页数：3

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