共 49 条
Short-Term In-Vitro Expansion Improves Monitoring and Allows Affordable Generation of Virus-Specific T-Cells against Several Viruses for a Broad Clinical Application
被引:33
作者:

Geyeregger, Rene
论文数: 0 引用数: 0
h-index: 0
机构:
St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria
St Anna Childrens Hosp, Childrens Canc Res Inst, FACS Core Unit, A-1090 Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Freimueller, Christine
论文数: 0 引用数: 0
h-index: 0
机构:
St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria
St Anna Childrens Hosp, Childrens Canc Res Inst, FACS Core Unit, A-1090 Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Stevanovic, Stefan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Immunol, Inst Cell Biol, Tubingen, Germany St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Stemberger, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria
St Anna Childrens Hosp, Childrens Canc Res Inst, FACS Core Unit, A-1090 Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Mester, Gabor
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Immunol, Inst Cell Biol, Tubingen, Germany St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Dmytrus, Jasmin
论文数: 0 引用数: 0
h-index: 0
机构:
St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria
St Anna Childrens Hosp, Childrens Canc Res Inst, FACS Core Unit, A-1090 Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Lion, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Pediat, Vienna, Austria
St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Mol Microbiol, A-1090 Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Rammensee, Hans-Georg
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机构:
Univ Tubingen, Dept Immunol, Inst Cell Biol, Tubingen, Germany St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Fischer, Gottfried
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h-index: 0
机构:
Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Eiz-Vesper, Britta
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机构:
Hannover Med Sch, Inst Transfus Med, Hannover, Germany St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Lawitschka, Anita
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Pediat, Vienna, Austria
St Anna Childrens Hosp, Dept Stem Cell Transplantat, A-1090 Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Matthes, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Med Univ Vienna, Dept Pediat, Vienna, Austria
St Anna Childrens Hosp, Dept Stem Cell Transplantat, A-1090 Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria

Fritsch, Gerhard
论文数: 0 引用数: 0
h-index: 0
机构:
St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria
St Anna Childrens Hosp, Childrens Canc Res Inst, FACS Core Unit, A-1090 Vienna, Austria
Med Univ Vienna, Dept Pediat, Vienna, Austria St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria
机构:
[1] St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Clin Cell Biol, A-1090 Vienna, Austria
[2] St Anna Childrens Hosp, Childrens Canc Res Inst, FACS Core Unit, A-1090 Vienna, Austria
[3] Med Univ Vienna, Dept Pediat, Vienna, Austria
[4] St Anna Childrens Hosp, Childrens Canc Res Inst, Dept Mol Microbiol, A-1090 Vienna, Austria
[5] Univ Tubingen, Dept Immunol, Inst Cell Biol, Tubingen, Germany
[6] Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, Vienna, Austria
[7] Hannover Med Sch, Inst Transfus Med, Hannover, Germany
[8] St Anna Childrens Hosp, Dept Stem Cell Transplantat, A-1090 Vienna, Austria
来源:
关键词:
ADENOVIRUS INFECTION;
ADOPTIVE TRANSFER;
PERIPHERAL-BLOOD;
IMMUNE RECONSTITUTION;
PEDIATRIC RECIPIENTS;
TRANSPLANT PATIENTS;
PREEMPTIVE THERAPY;
MULTIPLE VIRUSES;
CYTOMEGALOVIRUS;
CD8(+);
D O I:
10.1371/journal.pone.0059592
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Adenoviral infections are a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients. Adoptive transfer of donor-derived human adenovirus (HAdV)-specific T-cells represents a promising treatment option. However, the difficulty in identifying and selecting rare HAdV-specific T-cells, and the short time span between patients at high risk for invasive infection and viremia are major limitations. We therefore developed an IL-15-driven 6 to 12 day short-term protocol for in vitro detection of HAdV-specific T cells, as revealed by known MHC class I multimers and a newly identified adenoviral CD8 T-cell epitope derived from the E1A protein for the frequent HLA-type A*02: 01 and IFN-gamma. Using this novel and improved diagnostic approach we observed a correlation between adenoviral load and reconstitution of CD8(+) and CD4(+) HAdV-specific T-cells including central memory cells in HSCT-patients. Adaption of the 12-day protocol to good manufacturing practice conditions resulted in a 2.6-log (mean) expansion of HAdV-specific T-cells displaying high cytolytic activity (4-fold) compared to controls and low or absent alloreactivity. Similar protocols successfully identified and rapidly expanded CMV-, EBV-, and BKV-specific T-cells. Our approach provides a powerful clinical-grade convertible tool for rapid and cost-effective detection and enrichment of multiple virus-specific T-cells that may facilitate broad clinical application.
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页数:15
相关论文
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Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy

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Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy
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Felzmann, Thomas
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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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机构: Univ Tubingen, Childrens Hosp, Dept Paediat Haematol Oncol, D-72076 Tubingen, Germany

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