A Micro Electrochemical Sensor for Multi-Analyte Detection Based on Oxygenated Graphene Modified Screen-Printed Electrode

被引：6

作者：

Yuan, Baiqing ^{[1
]}

Gan, Liju ^{[1
]}

Li, Gang ^{[1
]}

Xu, Chunying ^{[1
]}

Liu, Gang ^{[1
]}

机构：

[1] Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China

来源：

NANOMATERIALS | 2022年 / 12卷 / 04期

关键词：

micro electrochemical sensor; multi-analyte detection; graphene oxide (GO); biofouling; oxo functionalities; URIC-ACID; REDUCED GRAPHENE; ASCORBIC-ACID; OXIDE ELECTROCATALYSTS; CATALYTIC OXIDATION; GUANINE; DOPAMINE; ADENINE; NANOCOMPOSITE; REDUCTION;

D O I：

10.3390/nano12040711

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrode interfaces with both antibiofouling properties and electrocatalytic activity can promote the practical application of nonenzymatic electrochemical sensors in biological fluids. Compared with graphene, graphene oxide (GO) possesses unique properties such as superior solubility (hydrophilicity) in water, negative charge, and abundant oxygenated groups (oxo functionalities) in the plane and edge sites, which play an essential role in electrocatalysis and functionalization. In this work, a micro electrochemical sensor consisting of GO-modified screen-printed electrode and PDMS micro-cell was designed to achieve multi-analyte detection with excellent selectivity and anti-biofouling properties by electrochemically tuning the oxygen-containing functional species, hydrophilicity/hydrophobicity, and electrical conductivity. In particular, the presented electrodes demonstrated the potential in the analysis of biological samples in which electrodes often suffer from serious biofouling. The interaction of proteins with electrodes as well as uric acid was investigated and discussed.

引用

页数：17

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