Formation of human prostate tissue from embryonic stem cells

被引：78
|
作者：
Taylor, RA
Cowin, PA
Cunha, GR
Pera, M
Trounson, AO
Pedersen, J
Risbridger, GP
机构：
[1] Monash Univ, Inst Med Res, Ctr Urol Res, Clayton, Vic, Australia
[2] Monash Univ, Monash Immunol & Stem Cell Labs, Clayton, Vic 3168, Australia
[3] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA
[4] Monash Univ, Australian Stem Cell Ctr, Clayton, Vic 3168, Australia
[5] TissuPath Labs, Hawthorn, Vic 3122, Australia
来源：
NATURE METHODS | 2006年 / 3卷 / 03期
关键词：
D O I：
10.1038/nmeth855
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Rodent models and immortalized or genetically modified Cell Lines are frequently used-but have limited utility-for studying human prostate development and maturation. Using rodent mesenchyme to establish reciprocal mesenchymal-epithelial Cell interactions with human embryonic stem cells (hESCs), we generated human prostate tissue expressing prostate-specific antigen (PSA) within 8-12 weeks. This human prostate model shows species-conserved signalling mechanisms that could extend to integumental, gastrointestinal and genital tissues.
引用
收藏
页码：179 / 181
页数：3
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