A prospective study on malnutrition and quality of life in patients with head and neck cancer

被引：80
作者：
van den Berg, Manon G. A. [1 ]
Rasmussen-Conrad, Ellen L. [1 ]
van Nispen, Lillian [1 ]
van Binsbergen, Jaap J. [2 ]
Merkx, Matthias A. W. [3 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Dietet, NL-6525 ED Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Gen Practice, NL-6525 ED Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Oral & Maxillofacial Surg, NL-6525 ED Nijmegen, Netherlands
来源：
ORAL ONCOLOGY | 2008年 / 44卷 / 09期
关键词：
malnutrition; quality of life; unintended weight loss; head and neck neoplasms;
D O I：
10.1016/j.oraloncology.2007.11.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The objective of this observational prospective study in patients with squamous cell carcinoma (SCC) of the oral, oropharyngeal. and hypopharyngeal. cavity was to took into the relation between malnutrition (>= 10% unintended weight loss within 6 months) and specific quality of life (QoL) parameters longitudinally. Bodyweight and QoL were monitored in 47 patients with SCC at diagnosis, end of treatment and six months after treatment. EORTC QoLQ-C30 and H&N 35 questionnaires were used to assess QoL. Significantly lower scores on the global QoL during treatment (p = 0.01) and revalidation (p = 0.02) were found for patients who had lost >= 10% compared to patients with <10% loss of weight within 6 month. Patients with radiotherapy and a treatment modality of radiotherapy with surgery or chemotherapy kept their unintended weight loss until the end of treatment. Patients with head and neck cancer treated with radiotherapy are specifically susceptible to malnutrition during treatment with no improvement in body weight or QoL. Professional preventive nutritional. support is therefore already required on diagnoses. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：830 / 837
页数：8
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