Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells

被引：31
作者：
Zhan, Yan-yan [1 ,2 ,3 ]
He, Jian-ping [3 ]
Chen, Hang-zi [3 ]
Wang, Wei-jia [3 ]
Cai, Jian-chun [1 ,2 ,4 ]
机构：
[1] Xiamen Univ, Dept Surg Oncol, Affiliated Hosp 1, Xiamen 361003, Fujian, Peoples R China
[2] Xiamen Canc Ctr, Xiamen 361003, Fujian, Peoples R China
[3] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361003, Fujian, Peoples R China
[4] Fujian Med Univ, Clin Med Coll 1, Fuzhou 350001, Fujian, Peoples R China
来源：
CANCER LETTERS | 2013年 / 329卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Nuclear orphan receptor TR3; Gastric cancer; Stem-like properties; Nanog; MESENCHYMAL TRANSITION PHENOTYPE; BREAST-CANCER; TRANSCRIPTION FACTORS; NUCLEAR RECEPTORS; EXPRESSION; NUR77; LINES; PLURIPOTENCY; NANOG; OVEREXPRESSION;
D O I：
10.1016/j.canlet.2012.09.022
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The orphan receptor TR3 is an important regulator of cell proliferation and apoptosis. However, whether TR3 is involved in regulating the stem-like properties of cancer cells remains unknown. The present study shows that TR3 expression is increased in gastric tumorsphere cells and is positively correlated with cancer stern cell (CSC) characteristics. Knocking down TR3 leads to the suppression of its stem-like properties in both gastric cancer cells and tumorsphere cells. This process involves the decreased expression of the sternness-related genes Oct-4 and Nanog and the invasion-related gene MMP-9. We further identify Nanog as a new target for the transcription factor TR3. Together, these data demonstrate for the first time that TR3 is essential for the maintenance of stem-like properties in human gastric cancer cells and implicate TR3 as a new therapeutic target for gastric cancer. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：37 / 44
页数：8
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