Organocatalytic, Regioselective Nucleophilic "Click" Addition of Thiols to Propiolic Acid Esters for Polymer-Polymer Coupling

被引：116

作者：

Truong, Vinh X. ^{[1
]}

Dove, Andrew P. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 15期

基金：

英国生物技术与生命科学研究理事会;

关键词：

alkines; click chemistry; polymers; regioselectivity; thiols; FREE-RADICAL ADDITION; ENE CLICK; YNE ADDITION; CHEMISTRY; ACETYLENES; HYDROGELS; EFFICIENT;

D O I：

10.1002/anie.201209239

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Discerning Tastes: The regioselectivity of the nucleophilic addition of thiols to electron-deficient alkynes is controlled by the choice of the solvent (i.e. the polarity of the reaction mixture) and the catalyst. Both thioalkenes and dithianes can be prepared in a rapid reaction that generates no by-products (see scheme). In turn the utility of this reaction is shown for efficient end-group modification of polymers. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4132 / 4136

页数：5

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