Common SNPs of AmelogeninX (AMELX) and Dental Caries Susceptibility

被引：26

作者：

Gasse, B. ^{[1
]}

Grabar, S. ^{[2
]}

Lafont, A. G. ^{[1
]}

Quinquis, L. ^{[2
]}

Vital, S. Opsahl ^{[3
]}

Davit-Beal, T. ^{[1
,4
]}

Moulis, E. ^{[5
]}

Chabadel, O. ^{[5
]}

Hennequin, M. ^{[6
,7
]}

Courson, F. ^{[8
]}

Droz, D. ^{[9
]}

Vaysse, F. ^{[10
]}

Laboux, O. ^{[11
]}

Tassery, H. ^{[12
,13
,14
]}

Al-Hashimi, N. ^{[1
]}

Boillot, A. ^{[15
,16
]}

Carel, J. C. ^{[17
]}

Treluyer, J. M. ^{[18
]}

Jeanpierre, M. ^{[19
]}

Beldjord, C. ^{[19
]}

Sire, J. Y. ^{[1
]}

Chaussain, C. ^{[3
]}

机构：

[1] Univ Paris 06, UMR 7138, F-75005 Paris, France

[2] Paris Descartes Univ, Hotel Dieu Hosp, AP HP, Dept Biostat & Epidemiol,Med Fac, Paris, France

[3] Univ Paris 05, PRES Sorbonne Paris Cite, Sch Dent, EA2496, Montrouge, France

[4] AP HP, Dept Pediat Dent, Ivry, France

[5] CHU Montpellier, Sch Dent, Dept Pediat Dent, Montpellier, France

[6] CHU Clermond Ferrand, Serv Odontol, Clermont Ferrand, France

[7] CHU Clermond Ferrand, EA3847, Clermont Ferrand, France

[8] Univ Paris 05, PRES Sorbonne Paris Cite, Sch Dent, EA4462, Montrouge, France

[9] CHU Nancy, Sch Dent, Dept Pediat Dent, Nancy, France

[10] CHU Toulouse, Sch Dent, Dept Pediat Dent, Toulouse, France

[11] CHU Nantes, Serv Odontol, Nantes, France

[12] Aix Marseille Univ, UFR Odontol, Marseille, France

[13] Hop Enfants La Timone, AP HM, Serv Odontol, Marseille, France

[14] Univ Montpellier I, UFR Odontol, EA 4203, F-34006 Montpellier, France

[15] Univ Paris Diderot, Sch Dent, Dept Periodontol, Paris, France

[16] Rothschild Hosp, AP HP, Serv Odontol, Paris, France

[17] Univ Paris Diderot, INSERM, CIE 5, Paris, France

[18] AP HP, Unite Rech Clin Paris Ctr, Paris, France

[19] Univ Paris 05, CNRS, INSERM, Inst Cochin,AP HP GDPM, Paris, France

来源：

JOURNAL OF DENTAL RESEARCH | 2013年 / 92卷 / 05期

关键词：

enamel; amelogenesis; genetic predisposition; mutation; clinical trial; social environment; EXPERIENCE; ENAMEL; ASSOCIATION; SCAN; GENE;

D O I：

10.1177/0022034513482941

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Genetic approaches have shown that several genes could modify caries susceptibility; AmelogeninX (AMELX) has been repeatedly designated. Here, we hypothesized that AMELX mutations resulting in discrete changes of enamel microstructure may be found in children with a severe caries phenotype. In parallel, possible AMELX mutations that could explain resistance to caries may be found in caries-free patients. In this study, coding exons of AMELX and exon-intron boundaries were sequenced in 399 individuals with extensive caries (250) or caries-free (149) individuals from nine French hospital groups. No mutation responsible for a direct change of amelogenin function was identified. Seven single-nucleotide polymorphisms (SNPs) were found, 3 presenting a high allele frequency, and 1 being detected for the first time. Three SNPs were located in coding regions, 2 of them being non-synonymous. Both evolutionary and statistical analyses showed that none of these SNPs was associated with caries susceptibility, suggesting that AMELX is not a gene candidate in our studied population.

引用

页码：418 / 424

页数：7

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