Evaluation of nutritional status in patients undergoing hematopoietic SCT

The aims of this study were to establish the nutritional status of patients during hematopoietic SCT (HSCT) and to determine if body mass index (BMI) is a valid indicator of nutritional status in this population when compared with nitrogen balance (NB). In total, 50 patients were enrolled (mean age: 25.7 +/- 9.0 years). Patients (14%) were underweight (BMI < 18.5 kg/m(2)), 58% in a normal BMI (between 18.5 and 24.9 kg/m(2)) and 28% were overweight or obese (BMI >= 25 kg/m(2)). NB dropped after transplantation and increased from days + 5 to + 20 after transplantation (P = 0.006). There was a significant negative relationship between patients' BMI and time to engraftment (r = -0.45, P = 0.001). Engraftment of underweight patients was 3.0 days (P = 0.002) and 4.0 days (P < 0.001) later than in normal and overweight or obese patients, respectively. There was no significant correlation between NB before transplantation and time to engraftment (r = -0.22, P = 0.16). The results of this study demonstrate that patients undergoing HSCT may have suboptimal nutritional status and that pre-HSCT-BMI rather than NB may have a greater correlation in HSCT patients with the time of engraftment. Therefore, it may be useful to consider patient's BMI before transplantation for earlier engraftment time.