Biomodulatory approaches to photodynamic therapy for solid tumors

被引：144
作者：
Anand, Sanjay [1 ,2 ]
Ortel, Bernhard J. [3 ]
Pereira, Stephen P. [4 ]
Hasan, Tayyaba [5 ]
Maytin, Edward V. [1 ,2 ,5 ]
机构：
[1] Cleveland Clin, Dept Dermatol, Cleveland, OH 44195 USA
[2] Cleveland Clin, Lerner Res Inst, Cleveland, OH 44195 USA
[3] Univ Chicago, Dermatol Sect, Chicago, IL 60637 USA
[4] UCL, UCL Inst Liver & Digest Hlth, London, England
[5] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
来源：
CANCER LETTERS | 2012年 / 326卷 / 01期
关键词：
ALA; PDT; Vitamin D; Differentiation; Porphyrin; PROTOPORPHYRIN IX ACCUMULATION; IRON-CHELATING AGENT; AMINOLEVULINIC ACID; BARRETTS-ESOPHAGUS; SKIN-CANCER; ENDOGENOUS PROTOPORPHYRIN; PAGETS-DISEASE; BILIARY-TRACT; IN-SITU; ABLATION;
D O I：
10.1016/j.canlet.2012.07.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Photodynamic Therapy (PDT) uses a photosensitizing drug in combination with visible light to kill cancer cells. PDT has an advantage over surgery or ionizing radiation because PDT can eliminate tumors without causing fibrosis or scarring. Disadvantages include the dual need for drug and light, and a generally lower efficacy for PDT vs. surgery. This minireview describes basic principles of PDT, photosensitizers available, and aspects of tumor biology that may provide further opportunities for treatment optimization. An emerging biomodulatory approach, using methotrexate or Vitamin D in combination with aminolevulinate-based PDT, is described. Finally, current clinical uses of PDT for solid malignancies are reviewed. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：8 / 16
页数：9
相关论文
共 91 条
  • [1] Apoptosis is an early event during phthalocyanine photodynamic therapy-induced ablation of chemically induced squamous papillomas in mouse skin
    Agarwal, R
    Korman, NJ
    Mohan, RR
    Feyes, DK
    Jawed, S
    Zaim, MT
    Mukhtar, H
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1996, 63 (04) : 547 - 552
  • [2] Photodynamic Therapy of Cancer: An Update
    Agostinis, Patrizia
    Berg, Kristian
    Cengel, Keith A.
    Foster, Thomas H.
    Girotti, Albert W.
    Gollnick, Sandra O.
    Hahn, Stephen M.
    Hamblin, Michael R.
    Juzeniene, Asta
    Kessel, David
    Korbelik, Mladen
    Moan, Johan
    Mroz, Pawel
    Nowis, Dominika
    Piette, Jacques
    Wilson, Brian C.
    Golab, Jakub
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) : 250 - 281
  • [3] Mechanism of cell death by 5-aminolevulinic acid-based photodynamic action and its enhancement by ferrochelatase inhibitors in human histiocytic lymphoma cell line U937
    Amo, Takashi
    Kawanishi, Noriaki
    Uchida, Masataka
    Fujita, Hirofumi
    Oyanagi, Eri
    Utsumi, Toshihiko
    Ogino, Tetsuya
    Inoue, Keiji
    Shuin, Taro
    Utsumi, Kozo
    Sasaki, Junzo
    [J]. CELL BIOCHEMISTRY AND FUNCTION, 2009, 27 (08) : 503 - 515
  • [4] Vitamin D3 Enhances the Apoptotic Response of Epithelial Tumors to Aminolevulinate-Based Photodynamic Therapy
    Anand, Sanjay
    Wilson, Clara
    Hasan, Tayyaba
    Maytin, Edward V.
    [J]. CANCER RESEARCH, 2011, 71 (18) : 6040 - 6050
  • [5] Low-Dose Methotrexate Enhances Aminolevulinate-Based Photodynamic Therapy in Skin Carcinoma Cells In vitro and In vivo
    Anand, Sanjay
    Honari, Golara
    Hasan, Tayyaba
    Elson, Paul
    Maytin, Edward V.
    [J]. CLINICAL CANCER RESEARCH, 2009, 15 (10) : 3333 - 3343
  • [6] Anderson CY, 1998, PHOTOCHEM PHOTOBIOL, V67, P332
  • [7] Photodynamic therapy with methyl aminolevulinate for atypia/carcinoma in situ of the penis
    Axcrona, Karol
    Brennhovd, Bjorn
    Alfsen, Glenny Cecilie
    Giercksky, Karl-Erik
    Warloe, Trond
    [J]. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 2007, 41 (06): : 507 - 510
  • [8] The Relationship of Phthalocyanine 4 (Pc 4) Concentrations Measured Noninvasively to Outcome of Pc 4 Photodynamic Therapy in Mice
    Bai, Lihua
    Guo, Jianxia
    Bontempo, Franklin A., III
    Eiseman, Julie L.
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2009, 85 (04) : 1011 - 1019
  • [9] Factors Influencing Tumor Response to Photodynamic Therapy Sensitized by Intratumor Administration of Methylene Blue
    Baran, Timothy M.
    Giesselman, Benjamin R.
    Hu, Rui
    Biel, Merrill A.
    Foster, Thomas H.
    [J]. LASERS IN SURGERY AND MEDICINE, 2010, 42 (08) : 728 - 735
  • [10] Photodynamic therapy treatment of early oral and laryngeal cancers
    Biel, Merrill A.
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2007, 83 (05) : 1063 - 1068
12345678910