The cAMP responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down regulation of RhoA activity

被引：0
|
作者：
Zieba, Bartosz Jakub [1 ,2 ]
Artamonov, Mykhaylo V. [2 ]
Jin, Li [2 ]
Momotani, Ko [2 ]
Ho, Ruoya [2 ]
Franke, Aaron S. [2 ]
Neppl, Ronald L. [2 ]
Stevenson, Andra S. [2 ]
Khromov, Alexander S. [2 ]
Chrzanowska-Wodnicka, Magdalena [3 ]
Somlyo, Avril V. [2 ]
机构：
[1] Jagiellonian Univ, Dept Cell Biochem, Krakow, Poland
[2] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA USA
[3] Blood Ctr SE Wisconsin Inc, Blood Res Inst, Milwaukee, WI 53233 USA
来源：
FASEB JOURNAL | 2011年 / 25卷
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：1
相关论文
共 45 条
  • [1] The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity
    Zieba, Bartosz J.
    Artamonov, Mykhaylo V.
    Jin, Li
    Momotani, Ko
    Ho, Ruoya
    Franke, Aaron S.
    Neppl, Ronald L.
    Stevenson, Andra S.
    Khromov, Alexander S.
    Chrzanowska-Wodnicka, Magdalena
    Somlyo, Avril V.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (19) : 16681 - 16692
  • [2] Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    Johan de Rooij
    Fried J. T. Zwartkruis
    Mark H. G. Verheijen
    Robbert H. Cool
    Sebastian M. B. Nijman
    Alfred Wittinghofer
    Johannes L. Bos
    Nature, 1998, 396 : 474 - 477
  • [3] Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    de Rooij, J
    Zwartkruis, FJT
    Verheijen, MHG
    Cool, RH
    Nijman, SMB
    Wittinghofer, A
    Bos, JL
    NATURE, 1998, 396 (6710) : 474 - 477
  • [4] Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1
    Kraemer, A
    Rehmann, HR
    Cool, RH
    Theiss, C
    de Rooij, J
    Bos, JL
    Wittinghofer, A
    JOURNAL OF MOLECULAR BIOLOGY, 2001, 306 (05) : 1167 - 1177
  • [5] H-Ras regulates the Rap1 guanine nucleotide exchange factor Epac2
    Quilliam, L
    Li, Y
    Rebhun, JF
    FASEB JOURNAL, 2003, 17 (05): : A1313 - A1314
  • [6] Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1
    Ichiba, T
    Hoshi, Y
    Eto, Y
    Tajima, N
    Kuraishi, Y
    FEBS LETTERS, 1999, 457 (01) : 85 - 89
  • [7] Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac
    Rehmann, H
    Schwede, F
    Doskeland, SO
    Wittinghofer, A
    Bos, JL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) : 38548 - 38556
  • [8] The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
    Li, Y
    Asuri, S
    Rebhun, JF
    Castro, AF
    Paranavitana, NC
    Quilliam, LA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (05) : 2506 - 2514
  • [9] Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac
    Rehmann, H
    Rueppel, A
    Bos, JL
    Wittinghofer, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (26) : 23508 - 23514
  • [10] PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2
    de Rooij, J
    Boenink, NM
    van Triest, M
    Cool, RH
    Wittinghofer, A
    Bos, JL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (53) : 38125 - 38130
12345