Bioactive fused heterocycles: Nucleoside analogs with an additional ring

被引：46

作者：

Jahnz-Wechmann, Zofia ^{[1
]}

Framski, Grzegorz ^{[1
]}

Januszczyk, Piotr ^{[1
]}

Boryski, Jerzy ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 97卷

关键词：

Fused heterocycles; Bioactive nucleosides; Ethenonucleosides; Furano[2,3-d]pyrimidine nucleosides; Pyrrolo[2,3-d]pyrimidine nucleosides; Antiviral activity; VARICELLA-ZOSTER-VIRUS; ACID RELATED-COMPOUNDS; BICYCLIC PYRIMIDINE NUCLEOSIDE; FLUORESCENT TRICYCLIC ANALOGS; ANTIVIRAL ACTIVITY; NUCLEIC-ACID; BIOLOGICAL EVALUATION; HIGHLY POTENT; SELECTIVE-INHIBITION; NUCLEOTIDE ANALOGS;

D O I：

10.1016/j.ejmech.2014.12.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The following mini-review summarizes the basic literature data regarding synthesis, biological activity, structure-activity relationship, and discussion of the mechanisms of action of two major classes of nucleoside analogs with fused heterocyclic rings: (i) the ethenonucleosides and their related derivatives of the 5,9-dihydro-3-glycosyl-6-alkyl-9-oxo-5H-imidazo[1,2-a]purine type; (ii) the bicyclic nucleosides of 6-alkyl-2,3-dihydrofurano[2,3-d]-pyrimidin-2(3H)-one and 6-alkyl-2,3-dihydropyrrolo[2,3-d]-pyrimidin-2(3H,7H)-one. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：388 / 396

页数：9

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