Introduction: Both coil and hook-wire localization techniques are commonly employed prior to video-assisted tho-racic surgery (VATS) resection in patients with lung nodules (LNs), but the relative advantages of each remain un-certain.Aim: This meta-analysis was performed to explore the relative safety and efficacy of coil localization (CL) and hook -wire localization (HWL) for patients with LNs.Material and methods: The PubMed, Embase, Cochrane Library, Wanfang, and CINK databases were searched to identify relevant studies published as of February 2022, after which pooled analyses of study outcomes were con-ducted.Results: In total, 8 studies met the inclusion criteria for the present meta-analysis. Successful localization rates were higher for the CL group relative to the HWL group (p = 0.0001). The CL group additionally exhibited significantly lower pooled total complication, pneumothorax, and lung hemorrhage rates relative to the HWL group (p = 0.01, p = 0.0001, p = 0.0009). Pooled duration of localization, VATS procedure duration, and wedge resection duration values were comparable in both groups (p = 0.69, p = 0.16, p = 0.76), as were chest pain scores (p = 0.06). When specifically analyzing the subset of patients with ground-glass LNs, pooled pneumothorax rates were significantly lower in the CL group relative to the HWL group (p = 0.03). Significant publication bias was detected with respect to rates of lung hemorrhage (Egger test, p = 0.029), but was not evident for other analyzed variables. Conclusions: These results suggest that the coil-based localization of LNs before VATS resection is safer and more effective than hook-wire localization.
