T-maze learning in weanling lambs

被引:5
|
作者
Johnson, Timothy B. [1 ,2 ]
Stanton, Mark E. [3 ]
Goodlett, Charles R. [4 ]
Cudd, Timothy A. [1 ,2 ]
机构
[1] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA
[2] Texas A&M Univ, Coll Vet Med & Biomed Sci, Michael E DeBakey Inst, College Stn, TX 77843 USA
[3] Univ Delaware, Dept Psychol, Newark, DE 19716 USA
[4] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46202 USA
关键词
sheep; ovine; matching-to-place; nonmatching-to-place; position habit; BINGE ALCOHOL EXPOSURE; FREELY-MOVING RAT; SPATIAL DELAYED ALTERNATION; GRADED RETROGRADE-AMNESIA; MEDIAL PREFRONTAL CORTEX; LONG-TERM STABILITY; MEMORY DEFICITS; WORKING-MEMORY; ANIMAL-MODEL; OVINE MODEL;
D O I
10.1002/dev.20624
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A major advantage of sheep models in experimental studies of neurodevelopmental disorders (e.g., with prenatal neurotoxicant exposure) is that the equivalent of all three trimesters of human brain development occurs in sheep entirely in utero. However, studies of learning and memory in sheep are limited. The goal of this study was to extend the analysis of spatial learning and memory in adolescent sheep using several traditional T-maze tasks. Both 9- and 14-week-old lambs acquired a delayed nonmatching-to-place task, but the older lambs learned the task significantly faster. In contrast, acquisition of a matching-to-place task was significantly more difficult. Lambs, like rodents, appear to have a predisposition toward learning win-shift spatial problems in a T-maze under appetitive motivation. Lambs also rapidly acquired a position habit and showed typical reversal learning curves. These findings support the use of T-maze tasks to assess behavioral outcomes in various sheep models. (c) 2011 Wiley Periodicals,Inc. Dev Psychobiol 54: 785797, 2012
引用
收藏
页码:785 / 797
页数:13
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