Low occurrence of the HLA-C*04:09N allele in a large Hungarian cohort

被引：4

作者：

Bors, A. ^{[1
]}

Inotai, D. ^{[2
]}

Andrikovics, H. ^{[1
]}

Benko, S. ^{[2
]}

Boros-Major, A. ^{[2
]}

Illes, Z. ^{[2
]}

Szilvasi, A. ^{[2
]}

Gelle-Hosso, A. ^{[3
]}

Rajczy, K. ^{[3
]}

Tordai, A. ^{[1
]}

机构：

[1] Hungarian Natl Blood Transfus Serv, Lab Mol Diagnost, H-1113 Budapest, Hungary

[2] Hungarian Natl Blood Transfus Serv, Lab Transplantat Immunogenet, H-1113 Budapest, Hungary

[3] Hungarian Natl Blood Transfus Serv, Bone Marrow Donor Registry, H-1113 Budapest, Hungary

来源：

TISSUE ANTIGENS | 2015年 / 86卷 / 01期

关键词：

common haplotype; HLA-C*04:09N; HLA-typing; Hungarian population; null-allele; HLA-CW-ASTERISK-0409N; COMMON;

D O I：

10.1111/tan.12587

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The presence of null alleles may affect the outcome of stem cell transplantation. HLA-C*04:09N was defined as common' with a frequency of 2-5/1000 in Caucasians, and its presence is routinely tested as part of haplotypes HLA-A*02:01/A*23:01-B*44:03-DRB1*07:01-DQB1*02:01. We aimed to investigate HLA-C*04:09N in a representative Hungarian cohort. HLA-typing data of 7345 unrelated persons were analyzed. The presence of HLA-C*04:09N was excluded in 157 chromosomes with either serology typing or with an allele-specific polymerase chain reaction for HLA-C*04:09N. HLA-C*04:09N was identified in a single chromosome with HLA-A*02, B*44, C*04, DRB1*07 resulting in a HLA-C*04:09N allele frequency of 0.0068% (1/14,690). This is approximately a 10- to 40-fold lower frequency compared with the previous data. Our results emphasize the need of precise local population-specific HLA-data, allowing appropriate modifications of local HLA-typing protocols.

引用

页码：32 / 35

页数：4

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