ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

被引：256

作者：

Mathew, Sam ^{[1
]}

Yun, Hyungdon ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Biotechnol, Gyongsan 712749, Gyeongbuk, South Korea

来源：

ACS CATALYSIS | 2012年 / 2卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

transaminase; biocatalysis; chiral amines; directed evolution; site directed mutagenesis; deracemization; kinetic resolution; asymmetric synthesis; unnatural amino acids; DYNAMIC KINETIC RESOLUTION; ASYMMETRIC-SYNTHESIS; CHIRAL AMINES; DIRECTED EVOLUTION; RATIONAL DESIGN; ALPHA-METHYLBENZYLAMINE; SUBSTRATE-SPECIFICITY; (S)-AMINO ACIDS; AMINOTRANSFERASE; ENZYMES;

D O I：

10.1021/cs300116n

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

omega-Transaminases have been increasingly used as efficient biocatalysts due to their ability to produce a wide range of optically pure amine compounds. Several approaches have been adopted, including screening, engineering, and development of new techniques in reaction systems for different aspects of the enzymes. This review summarizes the various methodologies and approaches adopted to produce enantiomerically pure amines and unnatural amino acids using omega-transaminases.

引用

页码：993 / 1001

页数：9

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