Emergence of SARS-CoV-2 through recombination and strong purifying selection

被引：265

作者：

Li, Xiaojun ^{[1
]}

Giorgi, Elena E. ^{[2
]}

Marichann, Manukumar Honnayakanahalli ^{[1
]}

Foley, Brian ^{[2
]}

Xiao, Chuan ^{[3
]}

Kong, Xiang-Peng ^{[4
]}

Chen, Yue ^{[1
]}

Korber, Bette ^{[2
,5
]}

Gao, Feng ^{[1
,6
]}

Gnanakaran, S. ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Los Alamos Natl Lab, Theoret Biol & Biophys, Los Alamos, NM 87544 USA

[3] Univ Texas El Paso, Dept Chem & Biochem, El Paso, TX 79968 USA

[4] NYU, Grossman Sch Med, Dept Biochem & Mol Pharmacol, New York, NY 10016 USA

[5] New Mexico Consortium, Los Alamos, NM 87545 USA

[6] Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Changchun 130012, Peoples R China

来源：

SCIENCE ADVANCES | 2020年 / 6卷 / 27期

关键词：

SARS-RELATED CORONAVIRUS; SPIKE; PROTEIN; INFECTION; BATS;

D O I：

10.1126/sciadv.abb9153

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis, discovering new drugs, and developing a vaccine. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike and other genes among bat, pangolin, and human coronaviruses, suggesting similar evolutionary constraints in different host species. We also demonstrate that SARS-CoV-2's entire RBM was introduced through recombination with coronaviruses from pangolins, possibly a critical step in the evolution of SARS-CoV-2's ability to infect humans. Similar purifying selection in different host species, together with frequent recombination among coronaviruses, suggests a common evolutionary mechanism that could lead to new emerging human coronaviruses.

引用

页数：11

共 50 条

[1] ICM - A NEW METHOD FOR PROTEIN MODELING AND DESIGN - APPLICATIONS TO DOCKING AND STRUCTURE PREDICTION FROM THE DISTORTED NATIVE CONFORMATION [J].