Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women

被引：191

作者：

Liang, Liang ^{[1
]}

Rasmussen, Marie-Louise Hee ^{[2
]}

Piening, Brian ^{[1
,9
]}

Shen, Xiaotao ^{[1
]}

Chen, Songjie ^{[1
]}

Rost, Hannes ^{[1
,10
]}

Snyder, John K. ^{[3
,4
]}

Tibshirani, Robert ^{[5
]}

Skotte, Line ^{[2
]}

Lee, Norman Cy ^{[3
,4
]}

Contrepois, Kevin ^{[1
]}

Feenstra, Bjarke ^{[2
]}

Zackriah, Hanyah ^{[6
]}

Snyder, Michael ^{[1
]}

Melbye, Mads ^{[2
,7
,8
]}

机构：

[1] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[2] Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

[3] Boston Univ, Dept Chem, Boston, MA 02215 USA

[4] Boston Univ, Chem Instrumentat Ctr, Boston, MA 02215 USA

[5] Stanford Univ, Dept Stat & Biomed Data Sci, Stanford, CA 94305 USA

[6] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[7] Univ Copenhagen, Dept Clin Med, DK-2200 Copenhagen, Denmark

[8] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[9] Providence Portland Med Ctr, Earle A Chiles Res Inst, Portland, OR 97213 USA

[10] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

来源：

CELL | 2020年 / 181卷 / 07期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

SYSTEMATIC ANALYSIS; GENE-EXPRESSION; PLASMA; PREECLAMPSIA; MORTALITY; PLACENTA; ESTRIOL; TRENDS; ACID; RISK;

D O I：

10.1016/j.cell.2020.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant women. Broad changes and a highly choreographed profile were revealed: 4,995 metabolic features (of 9,651 total), 460 annotated compounds (of 687 total), and 34 human metabolic pathways (of 48 total) were significantly changed during pregnancy. Using linear models, we built a metabolic clock with five metabolites that time gestational age in high accordance with ultrasound (R = 0.92). Furthermore, two to three metabolites can identify when labor occurs (time to delivery within two, four, and eight weeks, AUROC >= 0.85). Our study represents a weekly characterization of the human pregnancy metabolome, providing a high-resolution landscape for understanding pregnancy with potential clinical utilities.

引用

页码：1680 / +

页数：28

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