Plasma Fatty Add-Binding Protein 4, Nonesterified Fatty Acids, and Incident Diabetes in Older Adults

被引:34
作者
Djousse, Luc [1 ,2 ,3 ,4 ]
Khawaja, Owais [1 ,2 ,3 ,4 ]
Bartz, Traci M. [5 ,6 ]
Biggs, Mary L. [6 ]
Ix, Joachim H. [7 ,8 ]
Zieman, Susan J. [9 ]
Kizer, Jorge R. [10 ,11 ]
Tracy, Russell P. [12 ]
Siscovick, David S. [13 ]
Mukamal, Kenneth J. [14 ,15 ]
机构
[1] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Geriatr Res Educ & Clin Ctr, Boston, MA USA
[4] Boston Vet Affairs Healthcare Syst, Clin Ctr & Massachusetts Vet Epidemiol & Res Info, Boston, MA USA
[5] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[6] Vet Affairs San Diego Healthcare Syst, Nephrol Sect, San Diego, CA USA
[7] Univ Calif San Diego, Div Nephrol, San Diego, CA 92103 USA
[8] Univ Calif San Diego, Div Prevent Med, San Diego, CA 92103 USA
[9] NIA, NIH, Bethesda, MD 20892 USA
[10] Weill Cornell Med Coll, Dept Med, New York, NY USA
[11] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY USA
[12] Univ Vermont, Coll Med, Dept Pathol & Biochem, Burlington, VT USA
[13] Univ Washington, Dept Med & Epidemiol, Cardiovascular Hlth Res Unit, Seattle, WA USA
[14] Harvard Univ, Sch Med, Boston, MA USA
[15] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA 02215 USA
关键词
DE-NOVO LIPOGENESIS; METABOLIC SYNDROME; ADIPOSE-TISSUE; RISK; OBESITY; ATHEROSCLEROSIS; RESPONSES; WEIGHT; AP2;
D O I
10.2337/dc11-1690
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-To examine the relation of fatty acid binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. RESEARCH DESIGN AND METHODS-We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose >= 126 mg/dL, or nonfasting glucose >= 200 mg/cIL. FABP4 and NEFA were measured on specimens collected between 1992 and 1993. RESULTS-Mean age of the 3,740 subjects studied was 74.8 years. For each SD increase in log FABP4, hazard ratios (HRs) for diabetes were 1.35 (95% CI 1.10-1.65) for women and 1.45 (1.13-1.85) for men controlling for age, race, education, physical activity, cystatin C, alcohol intake, smoking, self-reported health status, and estrogen use for women (P for sex-FABP4 interaction 0.10). BMI modified the FABP4-diabetes relation (P = 0.009 overall; 0.02 for women and 0.135 for men), in that statistically significant higher risk of diabetes was mainly seen in men with BMI <25 kg/m(2) (HR per SD: 1.78 [95% CI 1.13-2.81]). There was a modest and nonsignificant association of NEFA with diabetes (P-trend = 0.21). However, when restricted to the first 5 years of follow-up, multivariable-adjusted HRs for diabetes were 1.0 (ref.), 1.68(95% CI 1.12-2.53), and 1.63 (1.07-2.50) across consecutive tertiles of NEFA (P-trend = 0.03). CONCLUSIONS-Plasma FABP4 was positively associated with incident diabetes in older adults, and such association was statistically significant in lean men only. A significant positive association between plasma NEFA and incident diabetes was observed during the first 5 years of follow-up.
引用
收藏
页码:1701 / 1707
页数:7
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