The Influence of Age and Gender on the Pro/Antioxidant Status in Young Healthy People

被引:0
|
作者
Kowalska, Katarzyna [1 ]
Milnerowicz, Halina [1 ]
机构
[1] Wroclaw Med Univ, Dept Biomed & Environm Anal, Fac Pharm, Borowska 211, PL-50556 Wroclaw, Poland
来源
ANNALS OF CLINICAL AND LABORATORY SCIENCE | 2016年 / 46卷 / 05期
关键词
age; gender; metals; oxidative stress markers; antioxidants; OXIDATIVE STRESS; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION; FREE-RADICALS; GLUTATHIONE; SMOKING; CELL; METALLOTHIONEIN; MALONDIALDEHYDE; PROGRESSION;
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
The aim of the present study was to examine the influence of age and gender on the pro/antioxidant balance in young healthy subject aged 20-40 years. The individuals were divided into women: aged 20-25 years (group A), aged 32-39 years (group B), and men aged 20-25 years (group C). In blood, the metals, markers of oxidative stress and antioxidants were estimated. The Cu level and Cu/Zn ratio in group B was higher than in group A. There were no differences in metals concentrations between groups A and C. The similar levels of malondialdehyde concentrations and gamma-glutamyl transpeptidase activities were observed in all groups. The decrease in glutathione reduced and glutathione peroxidase was in group B than in group A. The higher glutathione reduced, lower glutathione oxidized concentrations and glutathione-dependent enzymes (glutathione reductase and glutathione peroxidase) were observed in group C when compared to group A. The superoxide dismutase and catalase activities were higher in groups B and C than in group A. The age and gender have an influence on the pro/antioxidant status in healthy people aged 20-40 years. The main antioxidants responsible for the removal of free radicals in men aged 20-25 years and women aged 32-39 years are superoxide dismutase and catalase, while the glutathione peroxidase activity declines. The detoxification being mediated through glutathione is weakened in women aged 32-39 years.
引用
收藏
页码:480 / 488
页数:9
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