Two new steroidal compounds from starfish Asterias amurensis Lutken

被引：16
|
作者：
Liu, Hong-Wei [1 ,2 ]
Li, Jian-Kuan [3 ,4 ]
Zhang, Da-Wei [4 ,5 ]
Zhang, Jing-Chao [6 ]
Wang, Nai-Li [4 ,5 ]
Cai, Guo-Ping [2 ]
Yao, Xin-Sheng [4 ,5 ]
机构：
[1] Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China
[2] Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518057, Peoples R China
[3] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China
[4] Shenyang Pharmaceut Univ, Dept Nat Product Chem, Shenyang 110016, Peoples R China
[5] Tsinghua Univ Shenzhen, Key Iab Res & Dev Tradit Chinese Med & Nat Prod, Res Inst, Shenzhen 518057, Peoples R China
[6] Hebei Univ, Coll Chem Envirom Sci, Baoding 071002, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 06期
基金：
中国博士后科学基金;
关键词：
starfish; Asteria amurensis; steroid; UMR106 cell proliferation;
D O I：
10.1080/10286020801966674
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sulfated steroidal compounds (1 and 2), along with three known steroidal saponins (3, 4, and 5) were isolated from the starfish Asterias amurensis Lutken. The structures of new compounds were elucidated as 3 beta-O-sulfated-cholest-5-ene-7 alpha-ol (1) and (E) 25-O-beta-D-xylopyranosyl-26, 27-dinor-24(S)-methyl-22-ene-15 alpha-O-sulfated-5 alpha-cholest-3 beta,6 alpha-ol (2) by extensive NMR experiments and chemical evidence. Their effects on UMR106 cell proliferation were screened by MTT method. The results indicated that compounds 2 and 2a (0.01-100 mu M) significantly promoted the osteoblastic proliferation. The initial structure activity relationship analysis suggests that the sugar moiety is the necessary group for the activity.
引用
收藏
页码：521 / 529
页数：9
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