Two new steroidal compounds from starfish Asterias amurensis Lutken

被引：16
|
作者：
Liu, Hong-Wei [1 ,2 ]
Li, Jian-Kuan [3 ,4 ]
Zhang, Da-Wei [4 ,5 ]
Zhang, Jing-Chao [6 ]
Wang, Nai-Li [4 ,5 ]
Cai, Guo-Ping [2 ]
Yao, Xin-Sheng [4 ,5 ]
机构：
[1] Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, Peoples R China
[2] Tsinghua Univ, Grad Sch Shenzhen, Div Life Sci, Shenzhen 518057, Peoples R China
[3] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China
[4] Shenyang Pharmaceut Univ, Dept Nat Product Chem, Shenyang 110016, Peoples R China
[5] Tsinghua Univ Shenzhen, Key Iab Res & Dev Tradit Chinese Med & Nat Prod, Res Inst, Shenzhen 518057, Peoples R China
[6] Hebei Univ, Coll Chem Envirom Sci, Baoding 071002, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 06期
基金：
中国博士后科学基金;
关键词：
starfish; Asteria amurensis; steroid; UMR106 cell proliferation;
D O I：
10.1080/10286020801966674
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sulfated steroidal compounds (1 and 2), along with three known steroidal saponins (3, 4, and 5) were isolated from the starfish Asterias amurensis Lutken. The structures of new compounds were elucidated as 3 beta-O-sulfated-cholest-5-ene-7 alpha-ol (1) and (E) 25-O-beta-D-xylopyranosyl-26, 27-dinor-24(S)-methyl-22-ene-15 alpha-O-sulfated-5 alpha-cholest-3 beta,6 alpha-ol (2) by extensive NMR experiments and chemical evidence. Their effects on UMR106 cell proliferation were screened by MTT method. The results indicated that compounds 2 and 2a (0.01-100 mu M) significantly promoted the osteoblastic proliferation. The initial structure activity relationship analysis suggests that the sugar moiety is the necessary group for the activity.
引用
收藏
页码：521 / 529
页数：9
相关论文
共 50 条
  • [31] Polar steroidal compounds from the Far-Eastern starfish Lethasterias nanimensis chelifera
    Kicha, AA
    Ivanchina, NV
    Kalinovskii, AL
    Dmitrenok, PS
    Kainara, SO
    Aminin, DL
    Agafonova, IG
    Stonik, VA
    RUSSIAN CHEMICAL BULLETIN, 2004, 53 (02) : 447 - 454
  • [32] The antioxidant activities and neuroprotective effect of polysaccharides from the starfish Asterias rollestoni
    Zhang, Wenjing
    Wang, Jing
    Jin, Weihua
    Zhang, Quanbin
    CARBOHYDRATE POLYMERS, 2013, 95 (01) : 9 - 15
  • [33] Four New Steroidal Glycosides, Protolinckiosides A - D, from the Starfish Protoreaster lincki
    Malyarenko, Timofey V.
    Kicha, Alla A.
    Kalinovsky, Anatoly I.
    Ivanchina, Natalia V.
    Popov, Roman S.
    Pislyagin, Evgeny A.
    Menchinskaya, Ekaterina S.
    Padmakumar, Krishna Pillai
    Stonik, Valentin A.
    CHEMISTRY & BIODIVERSITY, 2016, 13 (08) : 998 - 1007
  • [34] Steroid compounds from two pacific starfish of the genus Evasterias
    Levina, E. V.
    Kalinovsky, A. I.
    Dmitrenok, P. V.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2009, 35 (01) : 123 - 130
  • [35] Two New Steroidal Saponins, Hylodoside A and Novaeguinoside Y, from the Starfish Leptasterias hylodes reticulata and Culcita novaeguineae (Juvenile)
    Levina, Eleonora V.
    Kalinovsky, Anatoly I.
    Dmitrenok, Pavel S.
    Martyyas, Ekaterina A.
    Stonik, Valentin A.
    NATURAL PRODUCT COMMUNICATIONS, 2010, 5 (11) : 1737 - 1742
  • [36] Steroid compounds from two pacific starfish of the genus Evasterias
    E. V. Levina
    A. I. Kalinovsky
    P. V. Dmitrenok
    Russian Journal of Bioorganic Chemistry, 2009, 35 : 123 - 130
  • [37] Six new polyhydroxylated steroids conjugated with taurine, microdiscusols A-F, from the Arctic starfish Asterias microdiscus
    Kicha, Alla A.
    Ivanchina, Natalia, V
    Malyarenko, Timofey, V
    Kalinovsky, Anatoly, I
    Popov, Roman S.
    Stonik, Valentin A.
    STEROIDS, 2019, 150
  • [38] Steroidal Constituents from the Starfish Astropecten polyacanthus and Their Anticancer Effects
    Nguyen Phuong Thao
    Nguyen Xuan Cuong
    Bui Thi Thuy Luyen
    Nguyen Hoai Nam
    Pham Van Cuong
    Nguyen Van Thanh
    Nguyen Xuan Nhiem
    Tran Thi Hong Hanh
    Kim, Eun-Ji
    Kang, Hee-Kyoung
    Phan Van Kiem
    Chau Van Minh
    Kim, Young Ho
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, 61 (10) : 1044 - 1051
  • [39] Purification and Characterization of α-N-Acetylgalactosaminidases I and II from the Starfish Asterina amurensis
    Harun-Or-Rashid, Md
    Matsuzawa, Tomomi
    Satoh, Youichi
    Shiraishi, Takayuki
    Ando, Masayuki
    Sadik, Golam
    Uda, Yutaka
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2010, 74 (02) : 256 - 261
  • [40] BIOLOGICALLY-ACTIVE GLYCOSIDES FROM ASTEROIDEA .31. GLYCOSPHINGOLIPIDS FROM THE STARFISH ASTERIAS-AMURENSIS VERSICOLOR SLADEN .2. STRUCTURE AND BIOLOGICAL-ACTIVITY OF GANGLIOSIDE MOLECULAR-SPECIES
    HIGUCHI, R
    INUKAI, K
    JHOU, JX
    HONDA, M
    KOMORI, T
    TSUJI, S
    NAGAI, Y
    LIEBIGS ANNALEN DER CHEMIE, 1993, (04): : 359 - 366
12345