Influence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study

被引：11
|
作者：
Giunta, Alessandro [1 ]
Babino, Graziella [1 ]
Ruzzetti, Manuela [1 ]
Manetta, Sara [1 ]
Chimenti, Sergio [1 ]
Esposito, Maria [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Dermatol, Viale Oxford 81, I-00133 Rome, Italy
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2016年 / 44卷
关键词：
Anti-tumor necrosis factor-; body mass index; body weight; etanercept; obesity; psoriasis; THERAPY;
D O I：
10.1177/0300060515593254
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim To investigate the role of body mass index (BMI) and weight in the long-term efficacy of etanercept in patients with psoriasis. Methods Medical records were retrospectively analysed. Extracted data included weight, BMI, comorbidities and psoriasis area severity index (PASI). Patients were stratified by weight (<80kg or 80kg) and BMI (healthy, BMI 22 - 24.99kg/m(2); overweight, BMI 25 - 29.99kg/m(2); obese, BMI 30kg/m(2)). Results The study included 66 patients. Body weight had no effect on etanercept efficacy. There was a significant reduction in etanercept efficacy in obese patients (n=12) compared with healthy weight (n=33) or overweight (n=21) patients. Conclusion Obesity has a negative effect on the efficacy of etanercept in psoriasis.
引用
收藏
页码：72 / 75
页数：4
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