Pneumothorax in connective tissue disease-associated interstitial lung disease

被引：17

作者：

Nishimoto, Koji ^{[1
]}

Fujisawa, Tomoyuki ^{[1
]}

Yoshimura, Katsuhiro ^{[1
]}

Enomoto, Yasunori ^{[1
]}

Yasui, Hideki ^{[1
]}

Hozumi, Hironao ^{[1
]}

Karayama, Masato ^{[1
]}

Suzuki, Yuzo ^{[1
]}

Furuhashi, Kazuki ^{[1
]}

Enomoto, Noriyuki ^{[1
]}

Nakamura, Yutaro ^{[1
]}

Inui, Naoki ^{[1
,2
]}

Sumikawa, Hiromitsu ^{[3
]}

Johkoh, Takeshi ^{[4
]}

Suda, Takafumi ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Internal Med, Div 2, Hamamatsu, Shizuoka, Japan

[2] Hamamatsu Univ Sch Med, Dept Clin Pharmacol & Therapeut, Hamamatsu, Shizuoka, Japan

[3] Sakai City Med Ctr, Dept Radiol, Sakai, Osaka, Japan

[4] Kansai Rosai Hosp, Dept Radiol, Amagasaki, Hyogo, Japan

来源：

PLOS ONE | 2020年 / 15卷 / 07期

基金：

日本学术振兴会;

关键词：

ENHANCED AUTOFLUORESCENCE THORACOSCOPY; AMERICAN-COLLEGE; CLASSIFICATION CRITERIA; PREDICTORS; MANAGEMENT; MORTALITY; SOCIETY;

D O I：

10.1371/journal.pone.0235624

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Spontaneous pneumothorax is a complication that occurs in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD); however, few studies on the clinical implications of pneumothorax for patients with CTD-ILD have been performed. Objectives This study aimed to investigate the incidence and prognostic significance of pneumothorax and the risk factors for its onset in patients with CTD-ILD. Methods This study included 140 consecutive patients with CTD-ILD. Clinical characteristics, laboratory findings, pulmonary function test results, and chest high-resolution computed tomography (HRCT) images were retrospectively evaluated. Results A total of 18 patients (12.9%) developed pneumothorax during their clinical course. The cumulative incidence of pneumothorax from the time of CTD-ILD diagnosis was 6.5%, 8.7%, and 11.3% at 1, 3, and 5 years, respectively. The 10-year survival rate was significantly lower in patients with pneumothorax (29.6%) than that in those without pneumothorax (81.3%). The development of pneumothorax was significantly associated with poor prognosis (HR 22.0; p < 0.010). Furthermore, a lower body mass index, greater extent of reticular abnormalities on HRCT, and administration of methylprednisolone pulse therapy were significantly associated with the development of pneumothorax. Conclusion Pneumothorax is a serious complication in the clinical course of patients with CTD-ILD and the onset of pneumothorax predicts a poor outcome.

引用

页数：12

共 31 条

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