Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status

被引：110

作者：

Hesari, AmirReza ^{[1
]}

Azizian, Mitra ^{[2
]}

Sheikhi, Alireza ^{[3
]}

Nesaei, Abolfazl ^{[4
]}

Sanaei, Shahin ^{[5
]}

Mahinparvar, Nazanin ^{[5
]}

Derakhshani, Maryam ^{[6
]}

Hedayt, Pegah ^{[6
]}

Ghasemi, Faezeh ^{[7
]}

Mirzaei, Hamed ^{[8
]}

机构：

[1] Arak Univ Med Sci, Dept Biotechnol, Mol & Med Res Ctr, Fac Med, Arak, Iran

[2] Shahid Beheshti Univ Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran

[3] Iran Univ Med Sci, Dept Med Biochem, Fac Med, Tehran, Iran

[4] Gonabad Univ Med Sci, Dept Basic Sci, Fac Med, Gonabad, Iran

[5] Isfahan Univ Med Sci, Esfahan, Iran

[6] Med Univ Isfahan, Dept Pathol, Esfahan, Iran

[7] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Next Milad Tower, Tehran, Iran

[8] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

来源：

INTERNATIONAL JOURNAL OF CANCER | 2019年 / 144卷 / 06期

关键词：

curcumin; esophageal cancer; MicroRNA; clinical trials; therapy; SQUAMOUS-CELL CARCINOMA; SUPEROXIDE-DISMUTASE EXPRESSION; FACTOR-KAPPA-B; CIRCULATING MICRORNAS; PROMOTES APOPTOSIS; CLINICAL-TRIAL; MELANOMA-CELLS; RISK-FACTORS; DIAGNOSTIC BIOMARKER; BARRETT-ESOPHAGUS;

D O I：

10.1002/ijc.31947

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Esophageal cancer is a common malignant tumor with an increasing trend during the past three decades. Currently, esophagectomy, often in combination with neoadjuvant chemo- and radiotherapy, is the cornerstone of curative treatment for esophageal cancer. However, esophagostomy is related to significant risks of perioperative mortality and morbidity, as well as lengthy recovery. Moreover, the adjuvant therapies including chemotherapy and radiotherapy are associated with numerous side effects, limiting compliance and outcome. The dietary agent curcumin has been extensively studied over the past few decades and is known to have many biological activities especially in regard to the prevention and potential treatment of cancer. This review summarizes the chemo-preventive and chemotherapeutic potential of curcumin in esophageal cancer in both preclinical and clinical settings.

引用

页码：1215 / 1226

页数：12

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