Patterns of immunohistochemical staining for P53 expression in hyperplastic endometrium and adenocarcinoma

被引：0
|
作者：
Terlikowski, S
Lenczewski, A
Famulski, W
Sulkowska, M
Dobrzycka, B
Stasiuk-Barmuta, A
Kulikowski, M
机构：
[1] Med Acad Bialystok, Dept Pathophysiol Pregnancy, PL-15276 Bialystok, Poland
[2] Med Acad Bialystok, Dept Clin Pathol, PL-15276 Bialystok, Poland
[3] Med Acad Bialystok, Dept Flow Cytometry, PL-15276 Bialystok, Poland
来源：
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2001年 / 39卷
关键词：
P53; gene; protein; endometrial hyperplasia; adenocarcinoma;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The p53, a tumour suppressor gene, is the most commonly mutated gene in human cancer, In this study, we performed immunohistochemical investigations of the expression of p53 protein in hyperplastic endometrium and adenocarcinoma. Positive immunostaining was detected in 7 (30%) cases of invasive adenocarcinoma, 2 (12%) cases of simple hyperplasia with atypia and 2 (14%) cases of complex hyperplasia with atypia. In simple and complex hyperplasia without atypia staining was seen in occasional cells. The results suggested that endometrial hyperplasia is not always accompanied by p53 protein accumulation, hence its expression is not an early exponent of the neoplastic process.
引用
收藏
页码：195 / 196
页数：2
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