Alignment of Gold Nanoparticle-Decorated DNA Origami Nanotubes: Substrate Prepatterning versus Molecular Combing

被引:35
|
作者
Teschome, Bezu [1 ,2 ]
Facsko, Stefan [1 ]
Gothelf, Kurt V. [3 ,4 ]
Keller, Adrian [5 ]
机构
[1] Helmholtz Zentrum Dresden Rossendorf, Inst Ion Beam Phys & Mat Res, D-01328 Dresden, Germany
[2] Tech Univ Dresden, D-01069 Dresden, Germany
[3] Aarhus Univ, Danish Natl Res Fdn, Ctr DNA Nanotechnol CDNA, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark
[4] Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark
[5] Univ Paderborn, Tech & Macromol Chem, D-33098 Paderborn, Germany
关键词
PATTERNED SURFACES; ARRAYS; NANOSTRUCTURES; SHAPES; SITES; TILES;
D O I
10.1021/acs.langmuir.5b02569
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
DNA origami has become an established technique for designing well-defined nanostructures with any desired shape and for the controlled arrangement of functional nanostructures with few nanometer resolution. These unique features make DNA origami nanostructures promising candidates for use as scaffolds in nanoelectronics and nanophotonics device fabrication. Consequently, a number of studies have shown the precise organization of metallic nanoparticles on various DNA origami shapes. In this work, we fabricated large arrays of aligned DNA origami decorated with a high density of gold nanoparticles (AuNPs). To this end, we first demonstrate the high-yield assembly of high-density AuNP arrangements on DNA origami adsorbed to Si surfaces with few unbound background nanoparticles by carefully controlling the concentrations of MgCl2 and AuNPs in the hybridization buffer and the hybridization time. Then, we evaluate two methods, i.e., hybridization to prealigned DNA origami and molecular combing in a receding meniscus, with respect to their potential to yield large arrays of aligned AuNP-decorated DNA origami nanotubes. Because of the comparatively low MgCl2 concentration required for the efficient immobilization of the AuNPs, the prealigned DNA origami become mobile and displaced from their original positions, thereby decreasing the alignment yield. This increased mobility, on the other hand, makes the adsorbed origami susceptible to molecular combing, and a total alignment yield of 86% is obtained in this way.
引用
收藏
页码:12823 / 12829
页数:7
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