Prevalence of fluoroquinolone-resistant rectal flora in patients undergoing transrectal ultrasound-guided prostate needle biopsy: A prospective multicenter study

被引：21

作者：

Chung, Ho Seok ^{[1
]}

Hwang, Eu Chang ^{[1
]}

Yu, Ho Song ^{[1
]}

Jung, Seung Il ^{[1
]}

Lee, Sun Ju ^{[2
]}

Lim, Dong Hoon ^{[3
]}

Cho, Won Jin ^{[3
]}

Choe, Hyun Sop ^{[4
]}

Lee, Seung-Ju ^{[4
]}

Park, Sung Woon ^{[5
]}

机构：

[1] Chonnam Natl Univ, Dept Urol, Sch Med, Gwangju, South Korea

[2] Kyung Hee Univ, Dept Urol, Sch Med, Seoul, South Korea

[3] Chosun Univ, Dept Urol, Sch Med, Gwangju, South Korea

[4] Catholic Univ Korea, St Vincents Hosp, Dept Urol, Suwon, South Korea

[5] Kwangju Christian Hosp, Dept Urol, Gwangju, South Korea

来源：

INTERNATIONAL JOURNAL OF UROLOGY | 2018年 / 25卷 / 03期

关键词：

biopsy; Escherichia coli; fluoroquinolone; infection; prostate; POSTOPERATIVE INFECTIOUS COMPLICATIONS; ANTIMICROBIAL PROPHYLAXIS; POVIDONE-IODINE; ESCHERICHIA-COLI; REDUCED INCIDENCE; INTESTINAL FLORA; SWAB CULTURES; MEN; RATES; RISK;

D O I：

10.1111/iju.13511

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectivesTo estimate the prevalence of fluoroquinolone-resistant rectal flora in patients undergoing transrectal ultrasound-guided prostate needle biopsy and to identify the high-risk groups. MethodsFrom January 2015 to March 2016, rectal swabs of 557 men who underwent transrectal ultrasound-guided prostate needle biopsy were obtained from five institutions. Clinical variables, including demographics, rectal swab culture results and infectious complications, were evaluated. Univariable and multivariable analyses were used to identify the risk factors for fluoroquinolone resistance of rectal flora and infectious complications. ResultsThe incidence of fluoroquinolone-resistant and extended-spectrum beta-lactamase production was 48.1 and 11.8%, respectively. The most common fluoroquinolone-resistant bacteria was Escherichia coli (81% of total fluoroquinolone-resistant bacteria, 39% of total rectal flora), and 16 (2.9%) patients had infectious complications. Univariable and multivariable analysis of clinical parameters affecting fluoroquinolone resistance showed no factor associated with fluoroquinolone resistance of rectal flora. The clinical parameter related to infectious complications after prostate biopsy was a history of operation within 6 months (relative risk 6.60; 95% confidence interval 1.99-21.8, P = 0.002). ConclusionsThese findings suggest that a risk-based approach by history taking cannot predict antibiotic resistance of rectal flora, and physicians should consider targeted antibiotic prophylaxis or extended antibiotic prophylaxis for Korean patients undergoing transrectal ultrasound-guided prostate biopsy because of high antibiotic resistance of rectal flora.

引用

页码：278 / 283

页数：6

共 30 条

[11] Risk factors for and prophylactic effect of povidone-iodine rectal cleansing on infectious complications after prostate biopsy: a retrospective cohort study [J].