Application and development of superparamagnetic nanoparticles in sample pretreatment and immunochromatographic assay

被引：63

作者：

Huang, Zhen ^{[1
]}

Hu, Song ^{[1
]}

Xiong, Yonghua ^{[1
]}

Wei, Hua ^{[1
]}

Xu, Hengyi ^{[1
]}

Duan, Hongwei ^{[2
]}

Lai, Weihua ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, 235 Nanjing East Rd, Nanchang 330047, Jiangxi, Peoples R China

[2] Nanyang Technol Univ, Sch Chem & Biomed Engn, 70 Nanyang Dr,N1-3,B3-14, Singapore 637457, Singapore

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2019年 / 114卷

基金：

中国国家自然科学基金;

关键词：

Superparamagnetic nanoparticles; Immunochromatographic assay; Magnetic separation; Food safety; Clinical diagnosis; Environmental monitoring; LATERAL-FLOW IMMUNOASSAY; IRON-OXIDE NANOPARTICLES; FUNCTIONALIZED MAGNETIC NANOPARTICLES; BACILLUS-ANTHRACIS SPORES; ESCHERICHIA-COLI O157H7; COMBINED IMMUNOMAGNETIC SEPARATION; ON-SITE DETECTION; RAPID DETECTION; LISTERIA-MONOCYTOGENES; SENSITIVE DETECTION;

D O I：

10.1016/j.trac.2019.03.004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Superparamagnetic nanoparticles (SMNPs) have been widely used in immunochromatographic assay (ICA) platform and achieved outstanding effects for overcoming the disadvantages of low sensitivity and poor matrix tolerance of ICA. The review presents the improvement of sensitivity and matrix tolerance of ICA due to immunomagnetic separation (IMS). Moreover, some novel magnetic separation technology, developed as new alternatives to IMS, based on non-antibody reagents are displayed to illustrate the novel concepts in various applications. SMNPs also act as a novel label for the signal output of ICA (SMNPs-ICA). This part focuses on examples of SMNPs-ICA based on optical and magnetic signal read modes to illustrate the advantage of SMNPs-ICA. At the same time, novel concepts in various sensors for magnetic reading and used as potential applications for screening tools are introduced. We also highlight the superiority of SMNPs aggregation-based, enzyme or nanozyme-based, and external magnetic field-based strategies for SMNPs-ICA. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：151 / 170

页数：20

共 217 条

[1]

Altenbach D, 2011, PHYTOPATHOLOGY, V101, pS6

[2] A multiplex magnetic capture hybridisation and multiplex Real-Time PCR protocol for pathogen detection in seafood [J].