Efficient N- and C-functionalisation of cyclam macrocycles utilising bisaminal methodology

被引:28
作者
Lewis, EA [1 ]
Allan, CC [1 ]
Boyle, RW [1 ]
Archibald, SJ [1 ]
机构
[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England
基金
英国惠康基金;
关键词
bifunctional macrocycles; cyclam; cyclisation; bisaminal;
D O I
10.1016/j.tetlet.2004.02.108
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient synthesis of C-functionalised cyclam macrocycles that employs bisaminal intermediates and allows N-substitution to be controlled is reported. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3059 / 3062
页数:4
相关论文
共 29 条
[1]  
Anderson C.J., 2003, Handbook of radiopharmaceuticals: radiochemistry and applications, P401, DOI DOI 10.1002/0470846380.CH12M
[2]  
[Anonymous], 2001, ACOUSTIC CHARACTERIZ
[3]   An organic template approach for the synthesis of selectively functionalised tetraazacycloalkanes [J].
Boschetti, F ;
Denat, F ;
Espinosa, E ;
Guilard, R .
CHEMICAL COMMUNICATIONS, 2002, (04) :312-313
[4]  
Brandes S, 1996, B SOC CHIM FR, V133, P65
[5]  
DENARDO GL, 1991, ANTIBODY IMMUNOCONJ, V4, P777
[6]  
Denat F, 2000, SYNLETT, P561
[7]  
DIAMANTINI G, 1993, SYNTHESIS-STUTTGART, P1104
[8]   SYNTHESIS OF NONIONIC GADOLINIUM CHELATES USEFUL AS CONTRAST AGENTS FOR MAGNETIC-RESONANCE-IMAGING - 1,4,7-TRIS(CARBOXYMETHYL)-10-SUBSTITUTED-1,4,7,10-TETRAAZACYCLODODECANES AND THEIR CORRESPONDING GADOLINIUM CHELATES [J].
DISCHINO, DD ;
DELANEY, EJ ;
EMSWILER, JE ;
GAUGHAN, GT ;
PRASAD, JS ;
SRIVASTAVA, SK ;
TWEEDLE, MF .
INORGANIC CHEMISTRY, 1991, 30 (06) :1265-1269
[9]   A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling [J].
Eisenwiener, KP ;
Powell, P ;
Mäcke, HR .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (18) :2133-2135
[10]   Siderophore analogues: a new macrocyclic tetraamine tris(hydroxamate) ligand; synthesis and solution chemistry of the iron(III), aluminium(III) and copper(II) complexes [J].
Gaspar, M ;
Grazina, R ;
Bodor, A ;
Farkas, E ;
Santos, MA .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1999, (05) :799-806