Chitosan beads for the delivery of salmon calcitonin: Preparation and release characteristics

被引：55

作者：

Aydin, Z ^{[1
]}

Akbuga, J ^{[1
]}

机构：

[1] UNIV MARMARA,FAC PHARM,DEPT PHARMACEUT TECHNOL,HAYDARPASA 81010,ISTANBUL,TURKEY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 131卷 / 01期

关键词：

salmon calcitonin; chitosan; controlled-release; chitosan-polyelectroylte complex;

D O I：

10.1016/0378-5173(95)04300-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Salmon calcitonin (sCT)-loaded chitosan beads were prepared by dropping a drug containing solution of chitosan into tripolyphosphate solution. The droplets instantaneously formed gelled spheres by ionotropic gelation. The mean diameter of beads was about 0.9 mm and encapsulation efficiency of drug was 54-59%. The drug was successfully encapsulated at pH 6. The amount of sCT did not affect the drug release from beads. Release data were examined kinetically and the mechanism was discussed. These results show that sCT-loaded chitosan beads could be prepared providing a controlled release property.

引用

页码：101 / 103

页数：3

共 9 条

[1] SPHERICAL AGGLOMERATES OF WATER-INSOLUBLE DRUGS [J].

BODMEIER, R ;

PAERATAKUL, O .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1989, 78 (11) :964-967

[2] PREPARATION AND EVALUATION OF DRUG-CONTAINING CHITOSAN BEADS [J].

BODMEIER, R ;

OH, KH ;

PRAMAR, Y .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1989, 15 (09) :1475-1494

[3]

CELEBI N, 1990, P INT S CONTROLLED R, V17, pA461

[4] INVIVO ASSESSMENT OF SALMON-CALCITONIN SUSTAINED-RELEASE FROM BIODEGRADABLE MICROSPHERES [J].

LEE, KC ;

SOLTIS, EE ;

NEWMAN, PS ;

BURTON, KW ;

MEHTA, RC ;

DELUCA, PP .

JOURNAL OF CONTROLLED RELEASE, 1991, 17 (02) :199-205

[5] NOVEL VAGINAL DELIVERY SYSTEMS FOR CALCITONIN .1. EVALUATION OF HYAFF CALCITONIN MICROSPHERES IN RATS [J].

RICHARDSON, JL ;

RAMIRES, PA ;

MIGLIETTA, MR ;

ROCHIRA, M ;

BACELLE, L ;

CALLEGARO, L ;

BENEDETTI, L .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 115 (01) :9-15

[6]

RITGER P L, 1987, Journal of Controlled Release, V5, P37, DOI 10.1016/0168-3659(87)90035-6

[7]

SEGRE G, 1985, CALCITONIN, P99

[8] CONTROLLED-RELEASE OF PIROXICAM FROM CHITOSAN BEADS [J].

SEZER, AD ;

AKBUGA, J .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1995, 121 (01) :113-116

[9] CONTROLLED-RELEASE OF INDOMETHACIN BY CHITOSAN-POLYELECTROLYTE COMPLEX - OPTIMIZATION AND IN-VIVO IN-VITRO EVALUATION [J].

SHIRAISHI, S ;

IMAI, T ;

OTAGIRI, M .

JOURNAL OF CONTROLLED RELEASE, 1993, 25 (03) :217-225

← 1 →