Spectroscopic identification and anti-biofilm properties of polar metabolites from the medicinal plant Helichrysum italicum against Pseudomonas aeruginosa

被引：37

作者：

D'Abrosca, Brigida ^{[1
]}

Buommino, Elisabetta ^{[2
]}

D'Angelo, Grazia ^{[1
]}

Coretti, Lorena ^{[2
]}

Scognamiglio, Monica ^{[1
]}

Severino, Valeria ^{[1
]}

Pacifico, Severina ^{[1
]}

Donnarumma, Giovanna ^{[2
]}

Fiorentino, Antonio ^{[1
]}

机构：

[1] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, I-81100 Caserta, Italy

[2] Univ Naples 2, Dept Expt Med, I-80138 Naples, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 22期

关键词：

Helichrysum italicum; Structural characterization; Spectroscopic analysis; Anti-biofilm activity; Pseudomonas aeruginosa; NEOLIGNAN GLYCOSIDES; RESISTANCE; MICROPHYLLUM; CONSTITUENTS; GLUCOSIDES; ARENARIUM; FLOWERS; PYRONE; LEAVES; ROOTS;

D O I：

10.1016/j.bmc.2013.09.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new acylated styrylpyrones, one 5-methoxy-1(3H)-isobenzofuranone glucoside and a hydroxymethyl-orcinol derivative, along with sixteen known aromatic metabolites, including lignans, quinic acid derivatives low-molecular weight phenol glucosides, have been isolated from the methanol extract of Helichrysum italicum, a medicinal plant typical of the Mediterranean vegetation. The structures of these compounds have been elucidated on the basis of extensive 2D-NMR spectroscopic analyses, including COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along with Q-TOF HRMS2 analysis. Selected compounds were evaluated for their anti-biofilm properties against Pseudomonas aeruginosa. (C) 2013 Published by Elsevier Ltd.

引用

页码：7038 / 7046

页数：9

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