Neuroglobin and Nogo-a as biomarkers for the severity and prognosis of traumatic brain injury

被引：12

作者：

Chen, Hao ^{[1
]}

Cao, He-Li ^{[1
]}

Chen, Shi-Wen ^{[1
]}

Guo, Yan ^{[1
]}

Gao, Wen-Wei ^{[1
]}

Tian, Heng-Li ^{[1
]}

Xue, Li-Xia ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Neurosurg, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Neurol, Shanghai 200030, Peoples R China

来源：

BIOMARKERS | 2015年 / 20卷 / 6-7期

关键词：

Biomarker; neuroglobin; Nogo-A; prognosis; traumatic brain injury; DOWN-REGULATION; EXPRESSION; OUTCOMES; IMPACT; MICE; RAT; MODELS; SCALE;

D O I：

10.3109/1354750X.2015.1094138

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis.Methods: Serum samples were obtained and analyzed from 34 patients with TBI within the first 96h after injury. Comparative analysis combined with Glasgow Coma Scale (GCS) scores and the 6-month prognosis of these patients was performed.Results: Significant correlations were found between peak serum neuroglobin and Nogo-A concentrations and a patient's GCS score on admission (p<0.001). The mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after injury (p<0.05).Conclusions: Serum neuroglobin and Nogo-A levels could be suggested as biomarkers for predicting TBI severity and prognosis.

引用

页码：495 / 501

页数：7

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