Neuroglobin and Nogo-a as biomarkers for the severity and prognosis of traumatic brain injury

被引：14
作者：
Chen, Hao [1 ]
Cao, He-Li [1 ]
Chen, Shi-Wen [1 ]
Guo, Yan [1 ]
Gao, Wen-Wei [1 ]
Tian, Heng-Li [1 ]
Xue, Li-Xia [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Neurosurg, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Neurol, Shanghai 200030, Peoples R China
来源：
BIOMARKERS | 2015年 / 20卷 / 6-7期
关键词：
Biomarker; neuroglobin; Nogo-A; prognosis; traumatic brain injury; DOWN-REGULATION; EXPRESSION; OUTCOMES; IMPACT; MICE; RAT; MODELS; SCALE;
D O I：
10.3109/1354750X.2015.1094138
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: To identify the early changes of serum neuroglobin and Nogo-A concentrations and the relations to traumatic brain injury (TBI) severity and prognosis.Methods: Serum samples were obtained and analyzed from 34 patients with TBI within the first 96h after injury. Comparative analysis combined with Glasgow Coma Scale (GCS) scores and the 6-month prognosis of these patients was performed.Results: Significant correlations were found between peak serum neuroglobin and Nogo-A concentrations and a patient's GCS score on admission (p<0.001). The mean peak serum neuroglobin and Nogo-A concentrations were both significantly higher in patients with an unfavorable outcome at 6 months after injury (p<0.05).Conclusions: Serum neuroglobin and Nogo-A levels could be suggested as biomarkers for predicting TBI severity and prognosis.
引用
收藏
页码：495 / 501
页数：7
相关论文
共 25 条
[1]   Guidelines for the Management of Severe Traumatic Brain Injury: Introduction [J].
不详 .
JOURNAL OF NEUROTRAUMA, 2007, 24 :S1-S106
[2]   Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression [J].
Chao, Po-Kuan ;
Lu, Kwok-Tung ;
Jhu, Ji-Yi ;
Wo, Yu-Yuan Peter ;
Huang, Tai-Chun ;
Ro, Long-Sun ;
Yang, Yi-Ling .
JOURNAL OF NEUROINFLAMMATION, 2012, 9
[3]   Neuroglobin Genetic Polymorphisms and Their Relationship to Functional Outcomes after Traumatic Brain Injury [J].
Chuang, Pei-Ying ;
Conley, Yvette P. ;
Poloyac, Samuel M. ;
Okonkwo, David O. ;
Ren, Dianxu ;
Sherwood, Paula R. ;
Hravnak, Marilyn ;
Alexander, Sheila A. .
JOURNAL OF NEUROTRAUMA, 2010, 27 (06) :999-1006
[4]   In Vivo Expression of Neuroglobin in Reactive Astrocytes During Neuropathology in Murine Models of Traumatic Brain Injury, Cerebral Malaria, and Autoimmune Encephalitis [J].
Dellavalle, Brian ;
Hempel, Casper ;
Kurtzhals, Jorgen A. L. ;
Penkowa, Milena .
GLIA, 2010, 58 (10) :1220-1227
[5]   Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat [J].
Di Pietro, Valentina ;
Lazzarino, Giacomo ;
Amorini, Angela Maria ;
Tavazzi, Barbara ;
D'Urso, Serafina ;
Longo, Salvatore ;
Vagnozzi, Roberto ;
Signoretti, Stefano ;
Clementi, Elisabetta ;
Giardina, Bruno ;
Lazzarino, Giuseppe ;
Belli, Antonio .
FREE RADICAL BIOLOGY AND MEDICINE, 2014, 69 :258-264
[6]   Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia [J].
Khan, Adil A. ;
Wang, Yaoming ;
Sun, Yunjuan ;
Mao, Xiao Ou ;
Xie, Lin ;
Miles, Erin ;
Graboski, Justin ;
Chen, Sylvia ;
Ellerby, Lisa M. ;
Jin, Kunlin ;
Greenberg, David A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (47) :17944-17948
[7]  
Li Zhen-Yan, 2012, Zhongguo Dang Dai Er Ke Za Zhi, V14, P697
[8]  
Lin Xin, 2010, Zhongguo Ying Yong Sheng Li Xue Za Zhi, V26, P39
[9]   Progesterone alters Nogo-A, GFAP and GAP-43 expression in a rat model of traumatic brain injury [J].
Liu, Feng ;
Liao, Fan ;
Li, Wei ;
Han, Yongfeng ;
Liao, Daguang .
MOLECULAR MEDICINE REPORTS, 2014, 9 (04) :1225-1231
[10]   Down-regulation of Nogo-A by collagen scaffolds impregnated with bone marrow stromal cell treatment after traumatic brain injury promotes axonal regeneration in rats [J].
Mahmood, Asim ;
Wu, Hongtao ;
Qu, Changsheng ;
Mahmood, Selina ;
Xiong, Ye ;
Kaplan, David ;
Chopp, Michael .
BRAIN RESEARCH, 2014, 1542 :41-48
123