Long-term therapy for chronic hepatitis B: Hepatitis B virus DNA suppression leading to cirrhosis reversal

被引：52

作者：

Marcellin, Patrick ^{[1
]}

Asselah, Tarik ^{[1
]}

机构：

[1] Univ Paris, Hop Beaujon, Serv Hepatol, F-92100 Clichy, France

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 28卷 / 06期

关键词：

chronic hepatitis B; cirrhosis; fibrosis; long term; nucleotide; nucleoside analogs; TENOFOVIR DISOPROXIL FUMARATE; SUSTAINED VIROLOGICAL RESPONSE; EXTENDED LAMIVUDINE TREATMENT; RENAL TUBULAR DYSFUNCTION; NO DETECTABLE RESISTANCE; ENTECAVIR TREATMENT; ADEFOVIR DIPIVOXIL; VIRAL SUPPRESSION; NAIVE PATIENTS; NUCLEOSIDE/NUCLEOTIDE ANALOGS;

D O I：

10.1111/jgh.12213

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Since the licensing of the first treatment for chronic hepatitis B in the nucleoside/tide analog class almost 15 years ago, considerable progress has been made in improving drug efficacy and safety with highly potent nucleoside/tide analogs exhibiting a high barrier to resistance. Physicians are now able to treat patients safely for many years and to be able to see convincing improvements in histology, including regression of fibrosis and even reversal of cirrhosis. The robust data that have been generated help us build confidence that we can now offer patients with chronic hepatitis B long-term, disease-modifying therapy that can alter the natural course of disease and help prevent the morbidity and mortality associated with it.

引用

页码：912 / 923

页数：12

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