BRD4 inhibition enhances the acalabrutinib tumor response by modulating PAX5 and interferon signaling in ABC-DLBCL

被引:0
|
作者
Oien, Derek B. [1 ]
Sharma, Samanta [1 ]
Xu, Ye [1 ]
Hattersley, Maureen [1 ]
DuPont, Michelle [1 ]
Burke, Kathleen [1 ]
Criscione, Steven W. [1 ]
Prickett, Laura [1 ]
Zhang, Jingwen [1 ]
Chan, Ho Man [1 ]
Drew, Lisa [1 ]
Yao, Yi [1 ]
机构
[1] AstraZeneca, Waltham, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3271
引用
收藏
页数:1
相关论文
共 8 条
  • [1] BET inhibition targets ABC-DLBCL constitutive B-cell receptor signaling through PAX5
    Oien, Derek B.
    Sharma, Samanta
    Hattersley, Maureen M.
    DuPont, Michelle
    Criscione, Steven W.
    Prickett, Laura
    Goeppert, Anne U.
    Drew, Lisa
    Yao, Yi
    Zhang, Jingwen
    Chan, Ho Man
    BLOOD ADVANCES, 2023, 7 (17) : 5108 - 5121
  • [2] BRD4 inhibitor tends to target BTK for suppression of ABC-DLBCL
    Zhang, E.
    Fan, Y.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 40 - 40
  • [3] BRD4抑制剂通过靶向BTK杀伤ABC-DLBCL细胞(英文)
    范志伟
    吴圆圆
    中国病理生理杂志, 2022, 38 (12) : 2164 - 2174
  • [4] Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer
    Gao, Xuemei
    Wu, Xinchao
    Zhang, Xiao
    Hua, Wenjuan
    Zhang, Yajing
    Maimaiti, Yusufu
    Gao, Zairong
    Zhang, Yongxue
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 469 (03) : 679 - 685
  • [5] Aberrant HCK Survival Signaling By Mutated MYD88 Requires PAX5 in Waldenstrom's Macroglobulinemia and ABC DLBCL Cells
    Liu, Xia
    Chen, Jiaji
    Munshi, Manit
    Xu, Lian
    Tsakmaklis, Nickolas
    Demos, Maria
    Kofides, Amanda
    Guerrera, Maria Luisa
    Chan, Gloria
    Patterson, Christopher
    Gustine, Joshua
    Castillo, Jorge J.
    Hunter, Zachary
    Treon, Steven P.
    Yang, Guang
    BLOOD, 2017, 130
  • [6] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
    Venkataraman, Sujatha
    Alimova, Irina
    Balakrishnan, Ilango
    Harris, Peter
    Birks, Diane K.
    Griesinger, Andrea
    Amani, Vladimir
    Cristiano, Brian
    Remke, Marc
    Taylor, Michael D.
    Handler, Michael
    Foreman, Nicholas K.
    Vibhakar, Rajeev
    ONCOTARGET, 2014, 5 (09) : 2355 - 2371
  • [7] Inhibition of BRD4 expression attenuates the inflammatory response and apoptosis by downregulating the HMGB-1/NF-κB signaling pathway following traumatic brain injury in rats
    Zhu, Yongkui
    Ni, Haibo
    Chen, Qian
    Qian, Huan
    Fang, Yiling
    Gao, Rong
    Liu, Bofei
    NEUROSCIENCE LETTERS, 2023, 812
  • [8] Inhibition of Nuclear Factor Kappa B (NFkB)/Interferon Regulatory Factor 4 (IRF4) Signaling Pathway in Activated B-Cell (ABC) Diffuse Large B-Cell Lymphoma (DLBCL) By Combining MLN4924, a Novel NEDD8 Activating Enzyme Inhibitor (NAE) and Ibrutinib
    Torka, Pallawi
    Hernandez-Ilizaliturri, Francisco J.
    Belliotti, Sarah
    Mavis, Cory
    Gu, Juan
    Czuczman, Myron S.
    BLOOD, 2014, 124 (21)